AIM: To explore the effect of baclofen on oesophageal acid exposure in patients with gastro-oesophageal reflux disease. METHODS AND MATERIALS: Twenty patients with established reflux disease were included in this double-blind, randomized, crossover study. Baclofen, 40 mg, or placebo was given as a single dose with a washout period of 4 weeks. Symptoms were assessed by a visual analogue scale. Oesophageal pH was registered for 12 h and analysed for the whole period and for the 0-4-h, 4-8-h, 8-12-h and 2-h post-prandial periods. RESULTS:Baclofen significantly reduced the number of reflux episodes during the 0-4-h (7.9 vs. 16.5, P < 0.0001; post-prandially: 6.0 vs. 11.2, P < 0.0001) and 0-12-h (46.5 vs. 73, P=0.0001; post-prandially: 18.8 vs. 29.3, P < 0.0001) periods. The fraction of time with pH < 4 was significantly lowered during the 0-4-h period (9.3 vs. 15.6, P=0.0019; post-prandially: 16.1 vs. 23.5, P=0.0083). Similar results were also obtained in patients with a hiatus hernia (n=13). Belching was significantly reduced (32 vs. 69 episodes, P < 0.01). CONCLUSIONS: A single oral dose of 40 mg baclofen significantly reduced both the number of reflux episodes and the fraction of time with pH < 4, an effect primarily found during the first 4 h after dosing.
RCT Entities:
AIM: To explore the effect of baclofen on oesophageal acid exposure in patients with gastro-oesophageal reflux disease. METHODS AND MATERIALS: Twenty patients with established reflux disease were included in this double-blind, randomized, crossover study. Baclofen, 40 mg, or placebo was given as a single dose with a washout period of 4 weeks. Symptoms were assessed by a visual analogue scale. Oesophageal pH was registered for 12 h and analysed for the whole period and for the 0-4-h, 4-8-h, 8-12-h and 2-h post-prandial periods. RESULTS:Baclofen significantly reduced the number of reflux episodes during the 0-4-h (7.9 vs. 16.5, P < 0.0001; post-prandially: 6.0 vs. 11.2, P < 0.0001) and 0-12-h (46.5 vs. 73, P=0.0001; post-prandially: 18.8 vs. 29.3, P < 0.0001) periods. The fraction of time with pH < 4 was significantly lowered during the 0-4-h period (9.3 vs. 15.6, P=0.0019; post-prandially: 16.1 vs. 23.5, P=0.0083). Similar results were also obtained in patients with a hiatus hernia (n=13). Belching was significantly reduced (32 vs. 69 episodes, P < 0.01). CONCLUSIONS: A single oral dose of 40 mg baclofen significantly reduced both the number of reflux episodes and the fraction of time with pH < 4, an effect primarily found during the first 4 h after dosing.
Authors: James A Slattery; Amanda J Page; Camilla L Dorian; Stuart M Brierley; L Ashley Blackshaw Journal: J Physiol Date: 2006-08-31 Impact factor: 5.182
Authors: M Kalinichev; T Donovan-Rodriguez; F Girard; E Riguet; M Rouillier; B Bournique; H Haddouk; V Mutel; S Poli Journal: Br J Pharmacol Date: 2014-09-05 Impact factor: 8.739
Authors: Anders Lehmann; Ann Aurell Holmberg; Ulhas Bhatt; Marianne Bremner-Danielsen; Lena Brändén; Susanne Elg; Thomas Elebring; Kevin Fitzpatrick; William B Geiss; Peter Guzzo; Jorgen Jensen; Gunilla Jerndal; Jan P Mattsson; Karolina Nilsson; Britt-Marie Olsson Journal: Br J Pharmacol Date: 2005-09 Impact factor: 8.739
Authors: P Malherbe; R Masciadri; R D Norcross; F Knoflach; C Kratzeisen; M-T Zenner; Y Kolb; A Marcuz; J Huwyler; T Nakagawa; R H P Porter; A W Thomas; J G Wettstein; A J Sleight; W Spooren; E P Prinssen Journal: Br J Pharmacol Date: 2008-04-21 Impact factor: 8.739