Literature DB >> 11965427

[Myelopathy due to vitamin B12 deficiency presenting as transverse myelitis].

Luiz Felipe Rocha Vasconcellos1, Rosalie Branco Correa, Leila Chimelli, Fernanda Nascimento, Adriane Baptista Fonseca, Janaina Nagel, Sergio Augusto Pereira Novis, Maurice Vincent.   

Abstract

Vitamin B12 deficiency may induce neuropathy, myelopathy, dementia and optic neuropathy. The diagnosis is established by vitamin B12, homocysteine and methylmalonic acid measurements. Myelin and axon destruction in the white matter of the spinal cord are observed. The posterior column of the cervical and thoracic level is the most common involved area. The involvement of the anterior column is restricted to advanced and relatively severe cases. Treatment is based on vitamin B12 injections, and the prognosis depends on the stage of vitamin deficiency and deterioration at treatment onset. We report a case with transverse myelitis due to vitamin B12 deficiency. This picture is relatively uncommon, however, we believe patients with transverse myelitis should have vitamin B12 studies as part of the diagnosis work up.

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Year:  2002        PMID: 11965427     DOI: 10.1590/s0004-282x2002000100028

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN: 0004-282X            Impact factor:   1.420


  2 in total

1.  Cobalamin deficiency, hyperhomocysteinemia, and dementia.

Authors:  Steven F Werder
Journal:  Neuropsychiatr Dis Treat       Date:  2010-05-06       Impact factor: 2.570

2.  Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association.

Authors:  Arthur Wagner Pimentel de Sousa; Vanessa Maia da Silva; Priscilla Alencar Fernandes; Daniel Uchôa Araújo; Gilmar Mamede de Carvalho; Erick José de Morais Villar; Mônica Souza de Miranda-Henriques
Journal:  GE Port J Gastroenterol       Date:  2015-01-12
  2 in total

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