| Literature DB >> 11965367 |
Mark R Burns1, Solveig LaTurner, Josh Ziemer, Maralee McVean, Bruce Devens, C Lance Carlson, Gerard F Graminski, Scott M Vanderwerf, Reitha S Weeks, Jay Carreon.
Abstract
A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues.Entities:
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Year: 2002 PMID： 11965367 DOI： 10.1016/s0960-894x(02)00156-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823