Literature DB >> 11964790

The role of interleukin-10 in critical illness.

Steven M. Opal1, Christian E. Huber.   

Abstract

Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in the molecular biology of IL-10 and its complex immune effects in experimental infection models are leading to new insights into therapeutic manipulation of IL-10 in patients with systemic inflammatory diseases.

Entities:  

Year:  2000        PMID： 11964790     DOI： 10.1097/00001432-200006000-00004

Source DB:  PubMed          Journal:  Curr Opin Infect Dis        ISSN： 0951-7375            Impact factor:   4.915


  6 in total

1.  Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users.

Authors:  J K Flynn; G J Dore; M Hellard; B Yeung; W D Rawlinson; P A White; J M Kaldor; A R Lloyd; R A Ffrench
Journal:  J Viral Hepat       Date:  2010-07-05       Impact factor: 3.728

2.  Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: a pilot study.

Authors:  Chris Winkelman
Journal:  Heart Lung       Date:  2010-04-08       Impact factor: 2.210

3.  IL-1beta induces an exaggerated pro- and anti-inflammatory response in peritoneal macrophages of children compared with adults.

Authors:  Katherine A Barsness; Denis D Bensard; David A Partrick; Casey M Calkins; Richard J Hendrickson; Anirban Banerjee; Robert C McIntyre
Journal:  Pediatr Surg Int       Date:  2004-04-21       Impact factor: 1.827

4.  Role of Programmed Cell Death in the Immunopathogenesis of Sepsis.

Authors:  Mario Perl; Chun-Shiang Chung; Ryan Swan; Alfred Ayala
Journal:  Drug Discov Today Dis Mech       Date:  2007

5.  Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment.

Authors:  Jacqueline K Flynn; Gregory J Dore; Margaret Hellard; Barbara Yeung; William D Rawlinson; Peter A White; John M Kaldor; Andrew R Lloyd; Rosemary A Ffrench
Journal:  J Gastroenterol Hepatol       Date:  2013-11       Impact factor: 4.029

Review 6.  The intimate relationship between human cytomegalovirus and the dendritic cell lineage.

Authors:  John Sinclair; Matthew Reeves
Journal:  Front Microbiol       Date:  2014-08-07       Impact factor: 5.640
  6 in total

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