Cutaneous manifestations of Penicillium marneffei infection.

From an almost unknown disease 15 years ago, Penicillium marneffei has emerged to become one of the most common opportunistic fungal pathogens among HIV-infected patients in the endemic area of southern China and northern Thailand. The mode of infection is primarily airborne, with the reticuloendothelial system as the main target. Penicilliosis is a fatal disease and systemic antifungals are the mainstay of therapy. Direct and mycological examinations are sufficient to make a diagnosis and to differentiate P. marneffei from other opportunistic fungi, although advances in serodiagnosis may potentially enhance understanding of the pathogenesis and identification of early asymptomatic cases.