| Literature DB >> 11964073 |
E T Boger1, J R Sellers, T B Friedman.
Abstract
A novel human myosin gene located at 17q25 was identified through evaluation of genomic DNA sequence and designated myosin XVBP since it resembled human myosin XVA. In humans, myosin XVBP along with an adjacent gene, Lethal Giant Larvae 2 (LLGL2) appears to have arisen from a genomic duplication of a chromosomal interval that included LLGL and an ancestral myosin XV. Inspection of human myosin XVBP predicted amino acid sequence from genomic DNA revealed that 36 of the 131 conserved amino acid residues of the motor domain are substituted or deleted, including sequence changes within the regions involved in the binding of ATP and actin. Twelve myosin XVBP overlapping cDNAs from kidney and stomach mRNA samples were cloned and sequenced. Analyses of these myosin XVBP cDNAs revealed numerous additional disablements including translational reading frame shifts resulting in stop codons. From these data we conclude that myosin XVBP is a transcribed, unprocessed pseudogene.Entities:
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Year: 2001 PMID： 11964073 DOI： 10.1023/a:1014507705858
Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698