Literature DB >> 11964005

Cytotoxic dammarane glycosides from processed ginseng.

Il Ho Park1, Long Zhu Piao, Sung Won Kwon, Yong Jae Lee, Sool Yeon Cho, Man Ki Park, Jeong Hill Park.   

Abstract

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 microM, respectively. Cisplatin had a GI50 of 84 microM in the same assay conditions.

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Year:  2002        PMID： 11964005     DOI： 10.1248/cpb.50.538

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  14 in total

Review 1.  Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine.

Authors:  Lee Jia; Yuqing Zhao; Xing-Jie Liang
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

2.  Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells.

Authors:  Ding-Fung Toh; Dhavalkumar Narendrabhai Patel; Eric Chun-Yong Chan; Alvin Teo; Soek-Ying Neo; Hwee-Ling Koh
Journal:  Chin Med       Date:  2011-01-24       Impact factor: 5.455

3.  Ginsenoside Rg3 reduces lipid accumulation with AMP-Activated Protein Kinase (AMPK) activation in HepG2 cells.

Authors:  Seohyun Lee; Mak-Soon Lee; Chong-Tai Kim; In-Hwan Kim; Yangha Kim
Journal:  Int J Mol Sci       Date:  2012-05-11       Impact factor: 6.208

4.  Effects of steaming on saponin compositions and antiproliferative activity of Vietnamese ginseng.

Authors:  Thi Hong Van Le; Seo Young Lee; Gwang Jin Lee; Ngoc Khoi Nguyen; Jeong Hill Park; Minh Duc Nguyen
Journal:  J Ginseng Res       Date:  2015-02-10       Impact factor: 6.060

5.  Decreased eccentric exercise-induced macrophage infiltration in skeletal muscle after supplementation with a class of ginseng-derived steroids.

Authors:  Szu-Hsien Yu; Chih-Yang Huang; Shin-Da Lee; Ming-Fen Hsu; Ray-Yau Wang; Chung-Lan Kao; Chia-Hua Kuo
Journal:  PLoS One       Date:  2014-12-11       Impact factor: 3.240

6.  Processed Panax ginseng, sun ginseng, inhibits the differentiation and proliferation of 3T3-L1 preadipocytes and fat accumulation in Caenorhabditis elegans.

Authors:  Hyejin Lee; Jinhee Kim; Jun Yeon Park; Ki Sung Kang; Joeng Hill Park; Gwi Seo Hwang
Journal:  J Ginseng Res       Date:  2016-05-04       Impact factor: 6.060

7.  Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts.

Authors:  Kyu Choon Song; Tong-Shin Chang; Hyejin Lee; Jinhee Kim; Jeong Hill Park; Gwi Seo Hwang
Journal:  J Ginseng Res       Date:  2012-01       Impact factor: 6.060

8.  Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast.

Authors:  Hyejin Lee; Joo Yeop Lee; Kyu Choon Song; Jinhee Kim; Jeong Hill Park; Kwang-Hoon Chun; Gwi Seo Hwang
Journal:  J Ginseng Res       Date:  2012-01       Impact factor: 6.060

9.  Processed Panax ginseng, Sun Ginseng, Decreases Oxidative Damage Induced by tert-butyl Hydroperoxide via Regulation of Antioxidant Enzyme and Anti-apoptotic Molecules in HepG2 Cells.

Authors:  Hyejin Lee; Jinhee Kim; Seo Young Lee; Jeong Hill Park; Gwi Seo Hwang
Journal:  J Ginseng Res       Date:  2012-07       Impact factor: 6.060

10.  Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity.

Authors:  Thi Hong Van Le; Seo Young Lee; Tae Ryong Kim; Jae Young Kim; Sung Won Kwon; Ngoc Khoi Nguyen; Jeong Hill Park; Minh Duc Nguyen
Journal:  J Ginseng Res       Date:  2013-12-17       Impact factor: 6.060
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