Literature DB >> 119638

Inhibition of the cytochrome P-450 multifunctional oxidase by N-propargyl analogs of SKF-525 A and acetylmethadol.

J L Kraus, J J Yaouanc.   

Abstract

New N-propargyl analogs of SKF-525A and acetyl methadol were tested for their inhibitory potency toward P-450 multifunctional oxidase. Metabolism of these analogs appears to be different from the metabolism of SKF-525 A itself; no N-dealkylated species were detected, --in vitro N-demethylation of aminopyrine and spectrofluorometric measurements support the hypothesis of an interaction between the hepatic flavo-protein and the acetylenic function of the inhibitors.

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Year:  1979        PMID： 119638     DOI： 10.1007/BF03189430

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  13 in total

1.  Enzymatic metabolism of drugs and other foreign compounds.

Authors:  B B BRODIE; J R GILLETTE; B N LA DU
Journal:  Annu Rev Biochem       Date:  1958       Impact factor: 23.643

2.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

Authors:  T NASH
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

3.  On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.

Authors:  M R Franklin; R W Estabrook
Journal:  Arch Biochem Biophys       Date:  1971-03       Impact factor: 4.013

4.  Flavoproteins of the mitochondrial respiratory chain.

Authors:  B Chance; L Ernster; P B Garland; C P Lee; P A Light; T Ohnishi; C I Ragan; D Wong
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205

5.  Dimethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A)--in vivo and in vitro effects of metabolism by rat liver microsomes--formation of an oxygenated complex.

Authors:  J B Schenkman; B J Wilson; D L Cinti
Journal:  Biochem Pharmacol       Date:  1972-09-01       Impact factor: 5.858

Review 6.  Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum.

Authors:  J R Gillette
Journal:  Adv Pharmacol       Date:  1966

7.  Inactivation of a flavin-linked oxidase, N,N-dimethylglycine oxidase, in vivo and in vitro.

Authors:  J L Kraus; J J Yaouanc
Journal:  Mol Pharmacol       Date:  1977-03       Impact factor: 4.436

8.  Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

Authors:  F P Guengerich
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

9.  Inhibition of drug metabolism. II. Metabolism of 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A).

Authors:  M W Anders; A P Alvares; G J Mannering
Journal:  Mol Pharmacol       Date:  1966-07       Impact factor: 4.436

10.  Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds.

Authors:  M W Anders; G J Mannering
Journal:  Mol Pharmacol       Date:  1966-07       Impact factor: 4.436
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