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Literature DB >> 1196303

The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism.

Abstract

The relationship between vitamin B12 and folate and the effect of methionine on folate metabolism during B12 deficiency in rats is best explained by the prevention of the accumulation of 5-methyl-H4PteGlu by vitamin B12 and/or methionine. Although several points remain to be clarified, the 'methyl trap' hypothesis provides the most satisfactory explanation for the relation between vitamin B12, methionine and folic acid. This concept is extended by the hypothesis that H4PteGlu is the most active substrate for pteroylpolyglutamate synthetase, and thus accounts for the effect of methionine or vitamin B12 increasing liver folate levels.

Entities: Chemical Species

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Year: 1975 PMID： 1196303 DOI： 10.1007/bf01732201

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

46 in total

1. Histidine metabolic loading test to distinguish folic acid deficiency from vit. B12 in megaloblastic anemias.

Authors: A L LUHBY; J M COOPERMAN; D N TELLER
Journal: Proc Soc Exp Biol Med Date: 1959-06

2. Observations on the metabolism of folic acid in pernicious anaemia.

Authors: A H WATERS; D L MOLLIN
Journal: Br J Haematol Date: 1963-07 Impact factor: 6.998

3. The urinary excretion of formic acid and formiminoglutamic acid in folic acid deficiency.

Authors: J C RABINOWITZ; H TABOR
Journal: J Biol Chem Date: 1958-07 Impact factor: 5.157

4. Urinary excretion of 5-methyltetrahydrofolate and liver S-adenosylmethionine levels of rats fed a vitamin B 12-deficient diet.

Authors: A J Vidal; E L Stokstad
Journal: Biochim Biophys Acta Date: 1974-09-05

5. Polygammaglutamyl metabolites of methotrexate.

Authors: C M Baugh; C L Krumdieck; M G Nair
Journal: Biochem Biophys Res Commun Date: 1973-05-01 Impact factor: 3.575

6. Identification of folic acid compounds in rat liver.

Authors: Y S Shin; M A Williams; E L Stokstad
Journal: Biochem Biophys Res Commun Date: 1972-04-14 Impact factor: 3.575

7. 7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.

Authors: J K Coward; K N Parameswaran; A R Cashmore; J R Bertino
Journal: Biochemistry Date: 1974-09-10 Impact factor: 3.162

The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism.

1. Histidine metabolic loading test to distinguish folic acid deficiency from vit. B12 in megaloblastic anemias.

2. Observations on the metabolism of folic acid in pernicious anaemia.

3. The urinary excretion of formic acid and formiminoglutamic acid in folic acid deficiency.

4. Urinary excretion of 5-methyltetrahydrofolate and liver S-adenosylmethionine levels of rats fed a vitamin B 12-deficient diet.

5. Polygammaglutamyl metabolites of methotrexate.

6. Identification of folic acid compounds in rat liver.

7. 7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.

8. Studies on the folic acid activity of human serum.

9. The synthesis of pteroylpolyglutamates by sheep liver enzymes in vitro.

10. Gluconeogenesis in the perfused rat liver.

Review 1. Cobalamin and folate: recent developments.

2. The regulation of folate and methionine metabolism.

3. Congenital folate malabsorption.

4. Distribution of pteroylglutamates in rat liver during regeneration after partial hepatectomy.