BACKGROUND: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. METHODS: Esophageal manometry and 24-h gastroesophageal pH monitoring with event data were performed in 18 mongrel dogs with a cervical esophagopexy. We then calculated a modified DeMeester score: The Duke Canine reflux score (DCR). Thereafter, the animals underwent a 4-cm anterior distal esophageal myotomy, incision of the left diaphragmatic crus, and intrathoracic gastric cardiopexy. Postoperative 24-h pH and manometry were obtained 2 weeks later. RESULTS: The postoperative 24-h pH results showed a significant increase in the mean DCR score (5.9 +/- 4.5 vs 84.9 +/- 56.1, p < 0.0002), and manometry indicated a significant decrease in mean lower esophageal sphincter (LES) pressure (7.1 +/- 2.9 vs 3.2 +/- 2.5 mmHg, p < 0.0001). CONCLUSION: This technique reliably creates a canine model of GERD.
BACKGROUND: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. METHODS: Esophageal manometry and 24-h gastroesophageal pH monitoring with event data were performed in 18 mongrel dogs with a cervical esophagopexy. We then calculated a modified DeMeester score: The Duke Canine reflux score (DCR). Thereafter, the animals underwent a 4-cm anterior distal esophageal myotomy, incision of the left diaphragmatic crus, and intrathoracic gastric cardiopexy. Postoperative 24-h pH and manometry were obtained 2 weeks later. RESULTS: The postoperative 24-h pH results showed a significant increase in the mean DCR score (5.9 +/- 4.5 vs 84.9 +/- 56.1, p < 0.0002), and manometry indicated a significant decrease in mean lower esophageal sphincter (LES) pressure (7.1 +/- 2.9 vs 3.2 +/- 2.5 mmHg, p < 0.0001). CONCLUSION: This technique reliably creates a canine model of GERD.
Authors: Evandro Silva Favarato; Maria Verônica de Souza; Paulo Renato dos Santos Costa; Luiz Gonzaga Pompermayer; Lukiya Silva Campos Favarato; José Ivo Ribeiro Júnior Journal: Vet Res Commun Date: 2011-04-02 Impact factor: 2.459
Authors: Toshitaka Hoppo; Barry P McMahon; Bart P L Witteman; Stefan J M Kraemer; Robert W O'Rourke; Flemming Gravesen; Nicole D Bouvy; Blair A Jobe Journal: J Gastrointest Surg Date: 2011-05-20 Impact factor: 3.452
Authors: Beat Peter Müller-Stich; Arianeb Mehrabi; Hannes Götz Kenngott; Zhoobin Mood; Hamidreza Funouni; Michael Andreas Reiter; Georg Richard Linke; Ulf Hinz; Carsten Nils Gutt; Jörg Köninger Journal: J Gastrointest Surg Date: 2008-05-23 Impact factor: 3.452
Authors: Johan Jirholt; Bengt Asling; Paul Hammond; Geoffrey Davidson; Mikael Knutsson; Anna Walentinsson; Jörgen M Jensen; Anders Lehmann; Lars Agreus; Maria Lagerström-Fermer Journal: PLoS One Date: 2011-04-28 Impact factor: 3.240