| Literature DB >> 11960276 |
T Taketani1, A Kikuchi, J Inatomi, R Hanada, H Kawaguchi, K Ida, T Oh-Ishi, T Arai, H Kishimoto, K Yamamoto.
Abstract
We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.Entities:
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Year: 2002 PMID： 11960276 DOI： 10.1038/sj.bmt.1703392
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483