| Literature DB >> 11960238 |
T A G M Huisman1, T Thiel, B Steinmann, G Zeilinger, E Martin.
Abstract
Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy ((1)H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, (1)H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.Entities:
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Year: 2001 PMID： 11960238 DOI： 10.1007/s003300101073
Source DB: PubMed Journal: Eur Radiol ISSN： 0938-7994 Impact factor: 5.315