Literature DB >> 11959614

Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumococci in experimental meningitis.

Philippe Cottagnoud1, Fernando Acosta, Marianne Cottagnoud, Martin G Täuber.   

Abstract

In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Deltalog(10)] CFU/ml/h, -0.68 +/- 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 +/- 0.09 deltalog(10) CFU/ml/h), in the treatment of meningitis due to a penicillin-resistant pneumococcal strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, gemifloxacin showed good bactericidal activity (-0.48 +/- 0.16 deltalog(10) CFU/ml/h). The excellent antibacterial activity of gemifloxacin was also confirmed by time-kill assays over 8 h in vitro.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11959614      PMCID： PMC127126          DOI： 10.1128/AAC.46.5.1607-1609.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  A study of the genetic material determining an enzyme in Pneumococcus.

Authors:  S LACKS; R D HOTCHKISS
Journal:  Biochim Biophys Acta       Date:  1960-04-22

Review 2.  A critical evaluation of vancomycin for treatment of bacterial meningitis.

Authors:  A Ahmed
Journal:  Pediatr Infect Dis J       Date:  1997-09       Impact factor: 2.129

3.  Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro.

Authors:  C M Gerber; M Cottagnoud; K Neftel; M G Täuber; P Cottagnoud
Journal:  J Antimicrob Chemother       Date:  2000-01       Impact factor: 5.790

Review 4.  The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s.

Authors:  J S Bradley; W M Scheld
Journal:  Clin Infect Dis       Date:  1997-02       Impact factor: 9.079

5.  Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis.

Authors:  I R Friedland; M Paris; S Ehrett; S Hickey; K Olsen; G H McCracken
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

6.  Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.

Authors:  R G Dacey; M A Sande
Journal:  Antimicrob Agents Chemother       Date:  1974-10       Impact factor: 5.191

7.  Microbioassay of antimicrobial agents.

Authors:  H J Simon; E J Yin
Journal:  Appl Microbiol       Date:  1970-04

Review 8.  Management of infections due to antibiotic-resistant Streptococcus pneumoniae.

Authors:  S L Kaplan; E O Mason
Journal:  Clin Microbiol Rev       Date:  1998-10       Impact factor: 26.132

9.  Rifampin for therapy of experimental pneumococcal meningitis in rabbits.

Authors:  R Nau; K Kaye; M Sachdeva; E R Sande; M G Täuber
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

10.  Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae.

Authors:  P Cottagnoud; J M Entenza; M Cottagnoud; Y A Que; P Moreillon; M G Taüber
Journal:  BMC Microbiol       Date:  2001-07-02       Impact factor: 3.605
View more
  2 in total

1.  Fluoroquinolones in the Treatment of Meningitis.

Authors:  Philippe Cottagnoud; Martin G. Täuber
Journal:  Curr Infect Dis Rep       Date:  2003-08       Impact factor: 3.725

2.  Biochemical Characterization of New Gemifloxacin Schiff Base (GMFX-o-phdn) Metal Complexes and Evaluation of Their Antimicrobial Activity against Some Phyto- or Human Pathogens.

Authors:  Hazem S Elshafie; Sadeek A Sadeek; Ippolito Camele; Amira A Mohamed
Journal:  Int J Mol Sci       Date:  2022-02-14       Impact factor: 5.923
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.