Literature DB >> 11959144

Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides.

Jyoti Srivastava1, Jozef Goris, Stephen M Dilworth, Peter J Parker.   

Abstract

The protein phosphatases PP1(c), PP2A(c) and PP2Calpha are shown to dephosphorylate protein kinase Cdelta (PKCdelta) in vitro; of these PP2A(c) displayed the highest specific activity towards PKCdelta. The role of PP2A(c) in the dephosphorylation of PKCdelta in cells was supported by the demonstration that these proteins could be co-immunoprecipitated from NIH3T3 cells. However the observation that binding of Mg-ATP to PKCdelta could protect the enzyme from dephosphorylation by PP2A(c) in vitro indicates that an additional input/factor is required for dephosphorylation in vivo.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11959144     DOI： 10.1016/s0014-5793(02)02500-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS).

Authors:  Peter E M Gibbs; Tihomir Miralem; Nicole Lerner-Marmarosh; Cicerone Tudor; Mahin D Maines
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

2.  The Role of Regulatory Domains in Maintaining Autoinhibition in the Multidomain Kinase PKCα.

Authors:  Ruth F Sommese; Michael Ritt; Carter J Swanson; Sivaraj Sivaramakrishnan
Journal:  J Biol Chem       Date:  2017-01-03       Impact factor: 5.157

Review 3.  Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

Authors:  Tung O Chan; John M Pascal; Roger S Armen; Ulrich Rodeck
Journal:  Cell Cycle       Date:  2012-02-01       Impact factor: 4.534

4.  Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Authors:  Tung O Chan; Jin Zhang; Ulrich Rodeck; John M Pascal; Roger S Armen; Maureen Spring; Calin D Dumitru; Valerie Myers; Xue Li; Joseph Y Cheung; Arthur M Feldman
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-26       Impact factor: 11.205

Review 5.  Protein kinase C: the "masters" of calcium and lipid.

Authors:  Peter Lipp; Gregor Reither
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-07-01       Impact factor: 10.005

6.  Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

Authors:  Christine M Gould; Corina E Antal; Gloria Reyes; Maya T Kunkel; Ryan A Adams; Ahdad Ziyar; Tania Riveros; Alexandra C Newton
Journal:  J Biol Chem       Date:  2011-06-29       Impact factor: 5.157

7.  Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

Authors:  Michelle A Lum; Gregor M Balaburski; Maureen E Murphy; Adrian R Black; Jennifer D Black
Journal:  J Biol Chem       Date:  2013-07-30       Impact factor: 5.157

8.  Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia.

Authors:  Tamara Egger; Rufina Schuligoi; Andrea Wintersperger; Rainer Amann; Ernst Malle; Wolfgang Sattler
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

9.  Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Authors:  Maya T Kunkel; Alexandra C Newton
Journal:  Chem Biol       Date:  2014-12-31

Review 10.  Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases.

Authors:  Roman Ginnan; Benjamin J Guikema; Katharine E Halligan; Harold A Singer; David Jourd'heuil
Journal:  Free Radic Biol Med       Date:  2008-01-22       Impact factor: 7.376
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.