Literature DB >> 11959006

Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.

Anton Copar1, Tadeja Prevec, Borut Anzic, Tomaz Mesar, Lovro Selic, Mateja Vilar, Tom Solmajer.   

Abstract

Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.

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Year:  2002        PMID： 11959006     DOI： 10.1016/s0960-894x(02)00061-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1.

Authors:  Adriana Fernea; Moreno Galleni; Jean-Marie Frère
Journal:  Antimicrob Agents Chemother       Date:  2016-01-04       Impact factor: 5.191

2.  In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor.

Authors:  Susanne Paukner; Lars Hesse; Andrej Prezelj; Tomaz Solmajer; Uros Urleb
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

Review 3.  Carbapenems: past, present, and future.

Authors:  Krisztina M Papp-Wallace; Andrea Endimiani; Magdalena A Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

Review 4.  Three decades of beta-lactamase inhibitors.

Authors:  Sarah M Drawz; Robert A Bonomo
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132
  4 in total

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