Literature DB >> 11959001

Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin.

Soko Kasai1, Hideko Nagasawa, Mariko Shimamura, Yoshihiro Uto, Hitoshi Hori.   

Abstract

We designed and synthesized the antiangiogenic arginine-rich dendrimers, TX-1943 and TX-1944, which mimic the surface structure of endostatin. TX-1944 containing 16 arginine residues is more similar in surface structure to endostatin than TX-1943 with eight arginine residues, and has stronger in vivo antiangiogenic activity at 10 microg/CAM in the chicken embryo chorioallantoic membrane (CAM) assay. TX-1944 also has stronger activity to bind heparin and to inhibit the growth of rat lung endothelial (RLE) cells than TX-1943.

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Year:  2002        PMID： 11959001     DOI： 10.1016/s0960-894x(02)00066-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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2.  Antithrombogenic properties of bioconjugate streptokinase-polyglycerol dendrimers.

Authors:  Edson Giuliani Ramos Fernandes; Alvaro Antonio Alencar de Queiroz; Gustavo A Abraham; Julio San Román
Journal:  J Mater Sci Mater Med       Date:  2006-02       Impact factor: 3.896

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-11       Impact factor: 11.205

4.  Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.

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5.  Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection.

Authors:  Fatemeh Sheikhi Mehrabadi; Hanxiang Zeng; Mark Johnson; Cathleen Schlesener; Zhibin Guan; Rainer Haag
Journal:  Beilstein J Org Chem       Date:  2015-05-13       Impact factor: 2.883

6.  Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.

Authors:  Philippe Abdel-Sayed; Ariane Kaeppeli; Ariane Kaeppli; Thissa Siriwardena; Tamis Darbre; Karl Perron; Paris Jafari; Jean-Louis Reymond; Dominique P Pioletti; Lee Ann Applegate
Journal:  Sci Rep       Date:  2016-02-25       Impact factor: 4.379

7.  Improved biological activity of a mutant endostatin containing a single amino-acid substitution.

Authors:  Y Yokoyama; S Ramakrishnan
Journal:  Br J Cancer       Date:  2004-04-19       Impact factor: 7.640

Review 8.  Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides.

Authors:  Colin V Bonduelle; Elizabeth R Gillies
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-12

9.  Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment.

Authors:  Kosuke Narise; Kensuke Okuda; Yukihiro Enomoto; Tasuku Hirayama; Hideko Nagasawa
Journal:  Drug Des Devel Ther       Date:  2014-06-06       Impact factor: 4.162
  9 in total

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