| Literature DB >> 11958999 |
Michael H Serrano-Wu1, Denis R St Laurent, Charles E Mazzucco, Terry M Stickle, John F Barrett, Dolatrai M Vyas, Balu N Balasubramanian.
Abstract
Oxime derivatives of the sordarin aglycone have been identified as potent antifungal agents. The in vitro spectrum of activity includes coverage against Candida albicans and Candida glabrata with MICs as low as 0.06 microg/mL. The antifungal activity was established to be exquisitely sensitive to the spatial orientation of the lipophilic side chains.Entities:
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Year: 2002 PMID： 11958999 DOI： 10.1016/s0960-894x(02)00054-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823