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Literature DB >> 11958992

Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding.

Waka Nakanishi¹, Kazuya Kikuchi, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano.

Abstract

Inositol 1,4,5-trisphosphate (IP(3)) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP(3) for strong binding to the IP(3) receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.

Entities: Chemical Gene

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Year: 2002 PMID： 11958992 DOI： 10.1016/s0960-894x(02)00044-6

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

Authors: Meng M Rowland; Heidi E Bostic; Denghuang Gong; Anna E Speers; Nathan Lucas; Wonhwa Cho; Benjamin F Cravatt; Michael D Best
Journal: Biochemistry Date: 2011-11-30 Impact factor: 3.162

2. Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

Authors: Takatoshi Yogo; Yasuteru Urano; Akiko Mizushima; Hisato Sunahara; Takanari Inoue; Kenzo Hirose; Masamitsu Iino; Kazuya Kikuchi; Tetsuo Nagano
Journal: Proc Natl Acad Sci U S A Date: 2008-01-02 Impact factor: 11.205

3. Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers.

Authors: Meng M Rowland; Denghuang Gong; Heidi E Bostic; Nathan Lucas; Wonhwa Cho; Michael D Best
Journal: Chem Phys Lipids Date: 2011-12-08 Impact factor: 3.329

Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding.

1. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

2. Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

3. Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers.

4. Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3.

Review 5. Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency.

6. A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.