| Literature DB >> 11958991 |
Toshiaki Matsui1, Takashi Kondo, Yoshitaka Nishita, Satoshi Itadani, Hiroshi Tsuruta, Setsuko Fujita, Nagashige Omawari, Masaru Sakai, Shuichi Nakazawa, Akihito Ogata, Hideaki Mori, Hiroyuki Ohno, Takaaki Obata, Hisao Nakai, Masaaki Toda.
Abstract
Metabolic stabilization of the chemical lead 1, which is a structurally novel inhibitor of TNF-alpha production, was accomplished by introducing a (1S)-methyl group into the optically active backbone. As a result, 2, 3 and 4 were identified as drug candidates and evaluated pharmacologically. The analysis of an active conformer was also carried out.Entities:
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Year: 2002 PMID： 11958991 DOI： 10.1016/s0960-894x(02)00037-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823