Literature DB >> 11958849

The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.

Matt Farrer1, Lisa Skipper, Marianne Berg, Gina Bisceglio, Melissa Hanson, John Hardy, Amanda Adam, Katrina Gwinn-Hardy, Jan Aasly.   

Abstract

We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64-11.10; P=2.17x10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.

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Year:  2002        PMID： 11958849     DOI： 10.1016/s0304-3940(02)00106-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  22 in total

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4.  Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

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