Literature DB >> 11958516

Subunit composition and function of GABAA receptors of rat spermatozoa.

Jing Hua Hu1, Xiao Bing He, Qi Wu, Yuan Chang Yan, S S Koide.   

Abstract

GABA triggers mammalian sperm acrosome reaction (AR). Here, evidence is presented, showing that rat spermatozoa contain GABAA receptors, composed of alpha5, beta1 and beta3 subunits. The effects of GABAA receptor agonist and antagonist on the induction of AR in rat spermatozoa were assessed using the chlortetracycline assay. Muscimol, a GABAA receptor agonist, triggered AR; whereas bicuculline, a GABAA receptor antagonist and picrotoxin, a GABAA receptor/Cl- channel blocker, inhibited the ability of GABA or progesterone to induce AR. In conclusion, GABAA receptors appear to mediate the action of progesterone in inducing AR in rat spermatozoa.

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Year:  2002        PMID： 11958516     DOI： 10.1023/a:1014876303062

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  21 in total

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  7 in total

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2.  Dynamic regulation of glutamate decarboxylase 67 gene expression by alternative promoters and splicing during rat testis maturation.

Authors:  Haixiong Liu; Yunbin Zhang; Shifeng Li; Yuanchang Yan; Yiping Li
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3.  Characteristic expressions of GABA receptors and GABA producing/transporting molecules in rat kidney.

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4.  Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by γ-aminobutyric acid.

Authors:  Hiroe Kon; Gen L Takei; Masakatsu Fujinoki; Motoo Shinoda
Journal:  J Reprod Dev       Date:  2014-03-10       Impact factor: 2.214

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Authors:  Masakatsu Fujinoki; Gen L Takei
Journal:  J Reprod Dev       Date:  2016-10-24       Impact factor: 2.214

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Journal:  Clin Exp Reprod Med       Date:  2021-02-22

7.  Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction.

Authors:  Samur Thanoi; Jureepon Roboon; Sutisa Nudmamud-Thanoi
Journal:  Int J Med Sci       Date:  2018-06-12       Impact factor: 3.738
  7 in total

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