BACKGROUND: To elucidate the role that cyclin E overexpression plays in the progression of early gastric cancer, we examined the expression of cyclin E and p53, as abnormal p53 expression is linked with cyclin E overexpression in exerting adverse affects on the cell cycle. METHODS: Specimens from 108 early gastric cancers were stained by an immunohistochemical method, using anti-cyclin E and anti- p53 antibodies. RESULTS: The positivity rate of cyclin E expression in early gastric cancer was 33% (36/108). Cyclin E-positive tumors invaded more deeply ( P < 0.05), infiltrated lymphatic vessels more frequently ( P < 0.01), showed a higher incidence of differentiated cancer ( P < 0.01), and more often expressed p53 ( P < 0.01) than cyclin E-negative tumors. Differentiated cancers showing coexpression of cyclin E and p53 were more likely to metastasize to the lymph nodes. CONCLUSIONS: Overexpression of cyclin E may promote the progression of early gastric cancer.
BACKGROUND: To elucidate the role that cyclin E overexpression plays in the progression of early gastric cancer, we examined the expression of cyclin E and p53, as abnormal p53 expression is linked with cyclin E overexpression in exerting adverse affects on the cell cycle. METHODS: Specimens from 108 early gastric cancers were stained by an immunohistochemical method, using anti-cyclin E and anti- p53 antibodies. RESULTS: The positivity rate of cyclin E expression in early gastric cancer was 33% (36/108). Cyclin E-positive tumors invaded more deeply ( P < 0.05), infiltrated lymphatic vessels more frequently ( P < 0.01), showed a higher incidence of differentiated cancer ( P < 0.01), and more often expressed p53 ( P < 0.01) than cyclin E-negative tumors. Differentiated cancers showing coexpression of cyclin E and p53 were more likely to metastasize to the lymph nodes. CONCLUSIONS: Overexpression of cyclin E may promote the progression of early gastric cancer.
Authors: Tony Bou Kheir; Ewa Futoma-Kazmierczak; Anders Jacobsen; Anders Krogh; Linda Bardram; Christoffer Hother; Kirsten Grønbæk; Birgitte Federspiel; Anders H Lund; Lennart Friis-Hansen Journal: Mol Cancer Date: 2011-03-18 Impact factor: 27.401
Authors: Christoph Treese; Pedro Sanchez; Patricia Grabowski; Erika Berg; Hendrik Bläker; Martin Kruschewski; Oliver Haase; Michael Hummel; Severin Daum Journal: PLoS One Date: 2016-12-28 Impact factor: 3.240