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Literature DB >> 11955440

Antigenic variation and allelic exclusion.

Abstract

Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here.

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Year: 2002 PMID： 11955440 DOI： 10.1016/s0092-8674(02)00711-0

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

66 in total

1. Variable var transition rates underlie antigenic variation in malaria.

Authors: Paul Horrocks; Robert Pinches; Zóe Christodoulou; Sue A Kyes; Chris I Newbold
Journal: Proc Natl Acad Sci U S A Date: 2004-07-15 Impact factor: 11.205

2. The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.

Authors: Jan-Peter Daniels; Keith Gull; Bill Wickstead
Journal: Eukaryot Cell Date: 2012-03-02

3. Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

Authors: Eleanor M Barnwell; Frederick J van Deursen; Laura Jeacock; Katherine A Smith; Rick M Maizels; Alvaro Acosta-Serrano; Keith Matthews
Journal: J Cell Sci Date: 2010-09-07 Impact factor: 5.285

4. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

Authors: Jill A Inverso; Timothy S Uphoff; Scott C Johnson; Donna M Paulnock; John M Mansfield
Journal: DNA Cell Biol Date: 2010-05 Impact factor: 3.311

5. PROTOGIM: a novel tool to search motifs and domains in hypothetical proteins of protozoan genomes.

Authors: Igor S Cestari; Nicolaas J Haver; Adriano Barbosa-Silva; Marcel I Ramirez
Journal: Parasitol Res Date: 2005-12-13 Impact factor: 2.289

6. Gene arrays at Pneumocystis carinii telomeres.

Authors: Scott P Keely; Hubert Renauld; Ann E Wakefield; Melanie T Cushion; A George Smulian; Nigel Fosker; Audrey Fraser; David Harris; Lee Murphy; Claire Price; Michael A Quail; Kathy Seeger; Sarah Sharp; Carolyn J Tindal; Tim Warren; Eduard Zuiderwijk; Barclay G Barrell; James R Stringer; Neil Hall
Journal: Genetics Date: 2005-06-18 Impact factor: 4.562

Antigenic variation and allelic exclusion.

1. Variable var transition rates underlie antigenic variation in malaria.

2. The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.

3. Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

4. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

5. PROTOGIM: a novel tool to search motifs and domains in hypothetical proteins of protozoan genomes.

6. Gene arrays at Pneumocystis carinii telomeres.

7. T-cell responses to the trypanosome variant surface glycoprotein are not limited to hypervariable subregions.

8. Mouse infection and pathogenesis by Trypanosoma brucei motility mutants.

9. Cohesin regulates VSG monoallelic expression in trypanosomes.

Review 10. Gene expression in trypanosomatid parasites.