Literature DB >> 119540

Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol. Predictive value of covalent binding in studies of target organ toxicities by reactive metabolites.

J S Dutcher, M R Boyd.   

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Year:  1979        PMID： 119540     DOI： 10.1016/0006-2952(79)90074-1

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  7 in total

1.  Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.

Authors:  Aaron M Teitelbaum; Matthew G McDonald; John P Kowalski; Oliver T Parkinson; Michele Scian; Dale Whittington; Katharina Roellecke; Helmut Hanenberg; Constanze Wiek; Allan E Rettie
Journal:  J Pharmacol Exp Ther       Date:  2018-11-08       Impact factor: 4.030

2.  Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.

Authors:  S Lakhanpal; R C Donehower; E K Rowinsky
Journal:  Invest New Drugs       Date:  2001       Impact factor: 3.850

3.  Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.

Authors:  Oliver T Parkinson; H Denny Liggitt; Allan E Rettie; Edward J Kelly
Journal:  Toxicol Sci       Date:  2013-06-07       Impact factor: 4.849

4.  Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.

Authors:  Oliver T Parkinson; Aaron M Teitelbaum; Dale Whittington; Edward J Kelly; Allan E Rettie
Journal:  Drug Metab Dispos       Date:  2016-07-28       Impact factor: 3.922

5.  Acute effects of 4-ipomeanol on experimental lung tumors with bronchiolar or alveolar cell features in Syrian hamsters or C3H/HeNCr mice.

Authors:  S Rehm; D E Devor
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

6.  Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.

Authors:  S K Durham; M R Boyd; W L Castleman
Journal:  Am J Pathol       Date:  1985-01       Impact factor: 4.307

7.  Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Authors:  Eva M Schmidt; Constanze Wiek; Oliver T Parkinson; Katharina Roellecke; Marcel Freund; Michael Gombert; Nadine Lottmann; Charles A Steward; Christof M Kramm; Vladimir Yarov-Yarovoy; Allan E Rettie; Helmut Hanenberg
Journal:  PLoS One       Date:  2015-09-10       Impact factor: 3.240
  7 in total

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