OBJECTIVE: To determine whether repeat screening for congenital hypothyroidism is necessary in newborns weighing <1500 g (very low birth weight [VLBW]). STUDY DESIGN: All VLBW infants born in the province of Québec between October 15, 1993, and October 15, 1994, had a second filter paper sample requested at 6 weeks of age to measure thyrotropin and thyroxine, in addition to these measurements for the routine screening sample. We then conducted a survey of all 4 academic pediatric endocrinology clinics in the province, inquiring about cases of permanent primary congenital hypothyroidism (PPCH) in children born weighing <1500 g or who may have been missed by neonatal screening. RESULTS: Two specimens were obtained in 465 VLBW newborns. One case of mild transient hyperthyrotropinemia was identified. The survey identified 4 VLBW newborns with PPCH: 1 girl and 1 boy with dyshormonogenesis, 1 athyreotic girl, and 1 girl with thyroid ectopy. All 4 were detected by their initial filter paper specimens. The survey also identified 1 case of PPCH in a girl who had a normal neonatal screen and normal birth weight. CONCLUSIONS: VLBW newborns with PPCH can mount an appropriate thyrotropin response and do not need repeat screening for congenital hypothyroidism.
OBJECTIVE: To determine whether repeat screening for congenital hypothyroidism is necessary in newborns weighing <1500 g (very low birth weight [VLBW]). STUDY DESIGN: All VLBW infants born in the province of Québec between October 15, 1993, and October 15, 1994, had a second filter paper sample requested at 6 weeks of age to measure thyrotropin and thyroxine, in addition to these measurements for the routine screening sample. We then conducted a survey of all 4 academic pediatric endocrinology clinics in the province, inquiring about cases of permanent primary congenital hypothyroidism (PPCH) in children born weighing <1500 g or who may have been missed by neonatal screening. RESULTS: Two specimens were obtained in 465 VLBW newborns. One case of mild transient hyperthyrotropinemia was identified. The survey identified 4 VLBW newborns with PPCH: 1 girl and 1 boy with dyshormonogenesis, 1 athyreotic girl, and 1 girl with thyroid ectopy. All 4 were detected by their initial filter paper specimens. The survey also identified 1 case of PPCH in a girl who had a normal neonatal screen and normal birth weight. CONCLUSIONS: VLBW newborns with PPCH can mount an appropriate thyrotropin response and do not need repeat screening for congenital hypothyroidism.
Authors: Susan R Rose; Christopher E Blunden; Olumide O Jarrett; Kyle Kaplan; Rheta Caravantes; Henry T Akinbi Journal: J Pediatr Date: 2021-11-06 Impact factor: 4.406
Authors: Hye Rim Chung; Choong Ho Shin; Sei Won Yang; Chang Won Choi; Beyong Il Kim; Ee Kyung Kim; Han Suk Kim; Jung Hwan Choi Journal: J Korean Med Sci Date: 2009-07-29 Impact factor: 2.153
Authors: Y Watanabe; E Sharwood; B Goodwin; M K Creech; H Y Hassan; M G Netea; M Jaeger; A Dumitrescu; S Refetoff; T Huynh; R E Weiss Journal: BMC Med Genet Date: 2018-05-02 Impact factor: 2.103