Literature DB >> 11953475

HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.

Marylyn M Addo1, Marcus Altfeld, Almas Rathod, Michelle Yu, Xu G Yu, Philip J R Goulder, Eric S Rosenberg, Bruce D Walker.   

Abstract

We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations.

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Year:  2002        PMID： 11953475     DOI： 10.1097/00002030-200205030-00015

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  7 in total

1.  Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes.

Authors:  Coral-Ann M Almeida; Corine Bronke; Steven G Roberts; Elizabeth McKinnon; Niamh M Keane; Abha Chopra; Carl Kadie; Jonathan Carlson; David W Haas; Sharon A Riddler; Richard Haubrich; David Heckerman; Simon Mallal; Mina John
Journal:  J Immunol       Date:  2011-08-05       Impact factor: 5.422

Review 2.  Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?

Authors:  Guido van Marle; Christopher Power
Journal:  J Neurovirol       Date:  2005-04       Impact factor: 2.643

3.  Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

Authors:  M M Addo; X G Yu; A Rathod; D Cohen; R L Eldridge; D Strick; M N Johnston; C Corcoran; A G Wurcel; C A Fitzpatrick; M E Feeney; W R Rodriguez; N Basgoz; R Draenert; David R Stone; C Brander; P J R Goulder; E S Rosenberg; M Altfeld; B D Walker
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

4.  Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.

Authors:  Marcus Altfeld; Marylyn M Addo; Raj Shankarappa; Paul K Lee; Todd M Allen; Xu G Yu; Almas Rathod; Jason Harlow; Kristin O'Sullivan; Mary N Johnston; Philip J R Goulder; James I Mullins; Eric S Rosenberg; Christian Brander; Bette Korber; Bruce D Walker
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

5.  A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

Authors:  Supranee Buranapraditkun; Ursula Hempel; Patrawadee Pitakpolrat; Rachel L Allgaier; Pattarawat Thantivorasit; Sven-Iver Lorenzen; Sunee Sirivichayakul; William H Hildebrand; Marcus Altfeld; Christian Brander; Bruce D Walker; Praphan Phanuphak; Pokrath Hansasuta; Sarah L Rowland-Jones; Todd M Allen; Kiat Ruxrungtham
Journal:  PLoS One       Date:  2011-08-22       Impact factor: 3.240

6.  Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

Authors:  Jingyan Chen; Nadine Tibroni; Daniel Sauter; Johanna Galaski; Toshiyuki Miura; Galit Alter; Birthe Mueller; Claudia Haller; Bruce D Walker; Frank Kirchhoff; Zabrina L Brumme; Takamasa Ueno; Oliver T Fackler
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240

7.  In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.

Authors:  Rachel Lubong Sabado; Daniel G Kavanagh; Daniel E Kaufmann; Karlhans Fru; Ethan Babcock; Eric Rosenberg; Bruce Walker; Jeffrey Lifson; Nina Bhardwaj; Marie Larsson
Journal:  PLoS One       Date:  2009-01-23       Impact factor: 3.240
  7 in total

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