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Literature DB >> 11953409

The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation.

Liselott A Svensson¹, Petra Henning, Teresa Lagergård.

Abstract

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G2 phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The antiproliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.

Entities: Chemical Disease Species

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Year: 2002 PMID： 11953409 PMCID： PMC127913 DOI： 10.1128/IAI.70.5.2665-2669.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

42 in total

1. Prevalence of cdtABC genes encoding cytolethal distending toxin among Haemophilus ducreyi and Actinobacillus actinomycetemcomitans strains.

Authors: H J Ahmed; L A Svensson; L D Cope; J L Latimer; E J Hansen; K Ahlman; J Bayat-Turk; D Klamer; T Lagergård
Journal: J Med Microbiol Date: 2001-10 Impact factor: 2.472

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Authors: L A Svensson; A Tarkowski; M Thelestam; T Lagergård
Journal: Microb Pathog Date: 2001-03 Impact factor: 3.738

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Journal: Infect Immun Date: 1992-03 Impact factor: 3.441

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Authors: A Frisk; M Lebens; C Johansson; H Ahmed; L Svensson; K Ahlman; T Lagergård
Journal: Microb Pathog Date: 2001-06 Impact factor: 3.738

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Authors: R S Young; K R Fortney; V Gelfanova; C L Phillips; B P Katz; A F Hood; J L Latimer; R S Munson; E J Hansen; S M Spinola
Journal: Infect Immun Date: 2001-03 Impact factor: 3.441

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Authors: V Gelfanova; E J Hansen; S M Spinola
Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

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Authors: L D Cope; S Lumbley; J L Latimer; J Klesney-Tait; M K Stevens; L S Johnson; M Purven; R S Munson; T Lagergard; J D Radolf; E J Hansen
Journal: Proc Natl Acad Sci U S A Date: 1997-04-15 Impact factor: 11.205

4 in total

1. Cytolethal distending toxin from Shiga toxin-producing Escherichia coli O157 causes irreversible G2/M arrest, inhibition of proliferation, and death of human endothelial cells.

Authors: Martina Bielaszewska; Bhanu Sinha; Thorsten Kuczius; Helge Karch
Journal: Infect Immun Date: 2005-01 Impact factor: 3.441