Literature DB >> 11952922

Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease.

Asako Takei1, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashiro.   

Abstract

Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado-Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-HT1A receptors, were also remarkably alleviated by treatment with tandospirone.

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Year:  2002        PMID： 11952922     DOI： 10.1046/j.1440-1819.2002.00952.x

Source DB:  PubMed          Journal:  Psychiatry Clin Neurosci        ISSN： 1323-1316            Impact factor:   5.188


  3 in total

Review 1.  Treatment of cerebellar ataxia with 5-HT1A agonist.

Authors:  Asako Takei; Takeshi Hamada; Ichiro Yabe; Hidenao Sasaki
Journal:  Cerebellum       Date:  2005       Impact factor: 3.847

2.  Difference in the effects of tandospirone on ataxia in various types of spinocerebellar degeneration: an open-label study.

Authors:  Asako Takei; Shinsuke Hamada; Sanae Homma; Keiko Hamada; Kunio Tashiro; Takeshi Hamada
Journal:  Cerebellum       Date:  2010-12       Impact factor: 3.847

Review 3.  Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado-Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies.

Authors:  Yu-Shuan Chen; Zhen-Xiang Hong; Shinn-Zong Lin; Horng-Jyh Harn
Journal:  Int J Mol Sci       Date:  2020-04-26       Impact factor: 5.923
  3 in total

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