Literature DB >> 1195275

Psychotomimetic phenylisopropylamines. 5. 4-Alkyl-2,5-dimethoxyphenylisopropylamines.

A T Shulgin, D C Dyer.   

Abstract

A homologous series of 4-alkyl-2,5-dimethoxyphenylisopropylamines (alkyl = H through n-C5H11 and t-C4H9) was synthesized and compared with mescaline as serotonin agonists in a sheep umbilical preparation. The three-carbon homolog 6d was found to be the most potent of the straight-chain series in accordance with its observed psychotomimetic effectiveness in man.

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Year:  1975        PMID： 1195275     DOI： 10.1021/jm00246a006

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  5HT-2 mediation of acute behavioral effects of hallucinogens in rats.

Authors:  L L Wing; G S Tapson; M A Geyer
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

2.  A characteristic effect of hallucinogens on investigatory responding in rats.

Authors:  M A Geyer; R K Light; G J Rose; L R Petersen; D D Horwitt; L M Adams; R L Hawkins
Journal:  Psychopharmacology (Berl)       Date:  1979-09       Impact factor: 4.530

3.  Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.

Authors:  Yi Zhang; Yong Sok Lee; Richard B Rothman; Christina M Dersch; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446

4.  Role of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice.

Authors:  Adam L Halberstadt; Susan B Powell; Mark A Geyer
Journal:  Neuropharmacology       Date:  2013-01-29       Impact factor: 5.250
  4 in total

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