Literature DB >> 11952345

Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase.

A Fidder1, A G Hulst, D Noort, R de Ruiter, M J van der Schans, H P Benschop, J P Langenberg.   

Abstract

In this paper a novel and general procedure is presented for detection of organophosphate-inhibited human butyrylcholinesterase (HuBuChE), which is based on electrospray tandem mass spectrometric analysis of phosphylated nonapeptides obtained after pepsin digestion of the enzyme. The utility of this method is exemplified by the positive analysis of serum samples from Japanese victims of the terrorist attack with sarin in the Tokyo subway in 1995.

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Year:  2002        PMID： 11952345     DOI： 10.1021/tx0101806

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  49 in total

1.  Development of a MALDI-TOF-MS method to identify and quantify butyrylcholinesterase inhibition resulting from exposure to organophosphate and carbamate pesticides.

Authors:  Jinchun Sun; Bert C Lynn
Journal:  J Am Soc Mass Spectrom       Date:  2007-01-16       Impact factor: 3.109

2.  Characterization of butyrylcholinesterase in bovine serum.

Authors:  Alicia J Dafferner; Sofya Lushchekina; Patrick Masson; Gaoping Xiao; Lawrence M Schopfer; Oksana Lockridge
Journal:  Chem Biol Interact       Date:  2017-02-08       Impact factor: 5.192

3.  Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry.

Authors:  Uma K Aryal; Chiann-Tso Lin; Jong-Seo Kim; Tyler H Heibeck; Jun Wang; Wei-Jun Qian; Yuehe Lin
Journal:  Anal Chim Acta       Date:  2012-02-19       Impact factor: 6.558

4.  Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.

Authors:  Mariya Liyasova; Bin Li; Lawrence M Schopfer; Florian Nachon; Patrick Masson; Clement E Furlong; Oksana Lockridge
Journal:  Toxicol Appl Pharmacol       Date:  2011-06-24       Impact factor: 4.219

Review 5.  Protein adducts as biomarkers of exposure to organophosphorus compounds.

Authors:  Judit Marsillach; Lucio G Costa; Clement E Furlong
Journal:  Toxicology       Date:  2012-12-20       Impact factor: 4.221

6.  Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.

Authors:  Yuan Yao; Junjun Liu; Chang-Guo Zhan
Journal:  Biochemistry       Date:  2012-10-23       Impact factor: 3.162

7.  A sensitive magnetic nanoparticle-based immunoassay of phosphorylated acetylcholinesterase using protein cage templated lead phosphate for signal amplification with graphite furnace atomic absorption spectrometry detection.

Authors:  Pei Liang; Caiyan Kang; Enjian Yang; Xiaoxiao Ge; Dan Du; Yuehe Lin
Journal:  Analyst       Date:  2016-04-07       Impact factor: 4.616

Review 8.  Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior.

Authors:  Patrick Masson; Oksana Lockridge
Journal:  Arch Biochem Biophys       Date:  2009-12-11       Impact factor: 4.013

9.  A high-throughput UHPLC-MS/MS method for the quantification of five aged butyrylcholinesterase biomarkers from human exposure to organophosphorus nerve agents.

Authors:  Leigh Ann Graham; Darryl Johnson; Melissa D Carter; Emily G Stout; Huseyin A Erol; Samantha L Isenberg; Thomas P Mathews; Jerry D Thomas; Rudolph C Johnson
Journal:  Biomed Chromatogr       Date:  2016-10-09       Impact factor: 1.902

10.  Magnetic electrochemical immunoassays with quantum dot labels for detection of phosphorylated acetylcholinesterase in plasma.

Authors:  Hua Wang; Jun Wang; Charles Timchalk; Yuehe Lin
Journal:  Anal Chem       Date:  2008-10-15       Impact factor: 6.986
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