Literature DB >> 11952087

A novel role of RGS9: inhibition of retinal guanylyl cyclase.

Vladimir A Bondarenko1, Hao Yu, Russell K Yamazaki, Akio Yamazaki.   

Abstract

Cyclic GMP plays a key role in retinal phototransduction and its photoreceptor concentration is precisely controlled by the cooperative action of cGMP phosphodiesterase (PDE) and retinal guanylyl cyclase (retGC). However, studies of the relationship between these two systems have focused only on a Ca2+-mediated, indirect connection. This article summarizes our studies strongly suggesting that RGS9-1 is directly involved in the cooperative action of PDE and retGC, and that this ingenious mechanism plays an important role in tuning of cGMP concentration in photoreceptors.

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Year:  2002        PMID： 11952087

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  29 in total

Review 1.  RGS proteins: more than just GAPs for heterotrimeric G proteins.

Authors:  L De Vries; M Gist Farquhar
Journal:  Trends Cell Biol       Date:  1999-04       Impact factor: 20.808

2.  Possible stimulation of retinal rod recovery to dark state by cGMP release from a cGMP phosphodiesterase noncatalytic site.

Authors:  A Yamazaki; V A Bondarenko; S Dua; M Yamazaki; J Usukura; F Hayashi
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157

Review 3.  Transduction mechanisms of vertebrate and invertebrate photoreceptors.

Authors:  S Yarfitz; J B Hurley
Journal:  J Biol Chem       Date:  1994-05-20       Impact factor: 5.157

Review 4.  Amplification and kinetics of the activation steps in phototransduction.

Authors:  E N Pugh; T D Lamb
Journal:  Biochim Biophys Acta       Date:  1993-03-01

5.  Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

Authors:  J B Hurley; L Stryer
Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

6.  The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.

Authors:  E R Makino; J W Handy; T Li; V Y Arshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

7.  Activation of retinal guanylyl cyclase-1 by Ca2+-binding proteins involves its dimerization.

Authors:  H Yu; E Olshevskaya; T Duda; K Seno; F Hayashi; R K Sharma; A M Dizhoor; A Yamazaki
Journal:  J Biol Chem       Date:  1999-05-28       Impact factor: 5.157

8.  Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.

Authors:  A Yamazaki; P J Stein; N Chernoff; M W Bitensky
Journal:  J Biol Chem       Date:  1983-07-10       Impact factor: 5.157

9.  Calcium modulation of cyclic GMP synthesis in rat visual cells.

Authors:  R N Lolley; E Racz
Journal:  Vision Res       Date:  1982       Impact factor: 1.886

10.  Flow of information in the light-triggered cyclic nucleotide cascade of vision.

Authors:  B K Fung; J B Hurley; L Stryer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
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  3 in total

Review 1.  Structure, function, and localization of Gβ5-RGS complexes.

Authors:  Vladlen Z Slepak
Journal:  Prog Mol Biol Transl Sci       Date:  2009-10-07       Impact factor: 3.622

Review 2.  Involvement of rhodopsin and ATP in the activation of membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC) by GC-activating proteins (GCAPs): a new model for ROS-GC activation and its link to retinal diseases.

Authors:  Vladimir A Bondarenko; Fumio Hayashi; Jiro Usukura; Akio Yamazaki
Journal:  Mol Cell Biochem       Date:  2009-11-26       Impact factor: 3.396

3.  Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization.

Authors:  Derek H Rosenzweig; K Saidas Nair; Konstantin Levay; Igor V Peshenko; John W Crabb; Alexander M Dizhoor; Vladlen Z Slepak
Journal:  Biochem J       Date:  2009-02-01       Impact factor: 3.857
  3 in total

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