BACKGROUND: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). OBJECTIVE: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. METHODS: A prospective study was done of all SCCs treated by the authors during one calendar year. RESULTS: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers (p = 0.005), and on patients who had a family history of skin cancer (p = 0.03). CONCLUSION: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.
BACKGROUND: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). OBJECTIVE: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. METHODS: A prospective study was done of all SCCs treated by the authors during one calendar year. RESULTS: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers (p = 0.005), and on patients who had a family history of skin cancer (p = 0.03). CONCLUSION: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.
Authors: Elias E Ayli; Susanne Dugas-Breit; Weijie Li; Christine Marshall; Liang Zhao; Marc Meulener; Thomas Griffin; Joel M Gelfand; John T Seykora Journal: Exp Dermatol Date: 2010-04-20 Impact factor: 3.960
Authors: Roy Chen; Jeffrey J Wargo; Amy Williams; Elizabeth Cates; Dan F Spandau; Christina Knisely; Jeffrey B Travers Journal: Lasers Surg Med Date: 2019-11-17 Impact factor: 4.025
Authors: Liang Zhao; Weijie Li; Christine Marshall; Thomas Griffin; Matthew Hanson; Ryan Hick; Tzvete Dentchev; Erik Williams; Adrienne Werth; Christopher Miller; Hasan Bashir; Warren Pear; John T Seykora Journal: Cancer Res Date: 2009-12-15 Impact factor: 12.701
Authors: Elena López-Tizón; Enrique Mencía-Gutiérrez; María Garrido-Ruíz; Esperanza Gutiérrez-Díaz; Fernando López-Ríos Journal: Int Ophthalmol Date: 2008-07-17 Impact factor: 2.031