Literature DB >> 11950569

Can we discover novel pathways using metabolomic analysis?

Wolfram Weckwerth1, Oliver Fiehn.   

Abstract

Metabolomic analysis aims at the identification and quantitation of all metabolites in a given biological sample. Current data acquisition and network analysis strategies are classified on the basis of pathway elucidation and characteristics of theoretical networks. The development of metabolomic methods and tools is progressing rapidly, but an understanding of the resulting data is limited owing to a fundamental lack of biochemical and physiological knowledge about network organization in plants.

Mesh:

Year:  2002        PMID: 11950569     DOI: 10.1016/s0958-1669(02)00299-9

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN: 0958-1669            Impact factor:   9.740


  31 in total

1.  Metabolic pathway relationships revealed by an integrative analysis of the transcriptional and metabolic temperature stress-response dynamics in yeast.

Authors:  Dirk Walther; Katrin Strassburg; Pawel Durek; Joachim Kopka
Journal:  OMICS       Date:  2010-06

2.  Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules.

Authors:  Douglas B Kell
Journal:  Mol Biol Rep       Date:  2002       Impact factor: 2.316

3.  Stochastic fluctuations in metabolic pathways.

Authors:  Erel Levine; Terence Hwa
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-18       Impact factor: 11.205

Review 4.  Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine.

Authors:  Yong-Min Lao; Jian-Guo Jiang; Lu Yan
Journal:  Br J Pharmacol       Date:  2009-06-05       Impact factor: 8.739

Review 5.  Dissecting plant secondary metabolism - constitutive chemical defences in cereals.

Authors:  Anne E Osbourn; Xiaoquan Qi; Belinda Townsend; Bo Qin
Journal:  New Phytol       Date:  2003-07       Impact factor: 10.151

Review 6.  A global approach to analysis and interpretation of metabolic data for plant natural product discovery.

Authors:  Manhoi Hur; Alexis Ann Campbell; Marcia Almeida-de-Macedo; Ling Li; Nick Ransom; Adarsh Jose; Matt Crispin; Basil J Nikolau; Eve Syrkin Wurtele
Journal:  Nat Prod Rep       Date:  2013-04       Impact factor: 13.423

7.  Metabolome Analysis of Multi-Connected Biparental Chromosome Segment Substitution Line Populations.

Authors:  Jie Chen; Jilin Wang; Wei Chen; Wenqiang Sun; Meng Peng; Zhiyang Yuan; Shuangqian Shen; Kun Xie; Cheng Jin; Yangyang Sun; Xianqing Liu; Alisdair R Fernie; Sibin Yu; Jie Luo
Journal:  Plant Physiol       Date:  2018-08-23       Impact factor: 8.340

8.  The perinatal transition of the circulating metabolome in a nonhuman primate.

Authors:  Andrew C Beckstrom; Pattaraporn Tanya; Elizabeth M Humston; Laura R Snyder; Robert E Synovec; Sandra E Juul
Journal:  Pediatr Res       Date:  2012-02-15       Impact factor: 3.756

9.  Time-dependent profiling of metabolites from Snf1 mutant and wild type yeast cells.

Authors:  Elizabeth M Humston; Kenneth M Dombek; Jamin C Hoggard; Elton T Young; Robert E Synovec
Journal:  Anal Chem       Date:  2008-10-01       Impact factor: 6.986

10.  Stability of metabolic correlations under changing environmental conditions in Escherichia coli--a systems approach.

Authors:  Jedrzej Szymanski; Szymon Jozefczuk; Zoran Nikoloski; Joachim Selbig; Victoria Nikiforova; Gareth Catchpole; Lothar Willmitzer
Journal:  PLoS One       Date:  2009-10-15       Impact factor: 3.240

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