Literature DB >> 11950563

Non-viral gene delivery systems.

Mark E Davis1.   

Abstract

Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability. In vivo, problems of extracellular non-specific interactions and intracellular trafficking to the nucleus are also encountered. Recent progress has been made in overcoming these issues.

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Year:  2002        PMID： 11950563     DOI： 10.1016/s0958-1669(02)00294-x

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  82 in total

1.  Transfection efficiency of pORF lacZ plasmid lipopolyplex to hepatocytes and hepatoma cells.

Authors:  Xun Sun; Hong-Wei Zhang; Zhi-Rong Zhang
Journal:  World J Gastroenterol       Date:  2004-02-15       Impact factor: 5.742

2.  Off-the-shelf adenoviral-mediated immunotherapy via bicistronic expression of tumor antigen and iMyD88/CD40 adjuvant.

Authors:  Jan Ole Kemnade; Mamatha Seethammagari; Priya Narayanan; Jonathan M Levitt; Alison A McCormick; David M Spencer
Journal:  Mol Ther       Date:  2012-03-20       Impact factor: 11.454

Review 3.  Applying horizontal gene transfer phenomena to enhance non-viral gene therapy.

Authors:  Jacob J Elmer; Matthew D Christensen; Kaushal Rege
Journal:  J Control Release       Date:  2013-08-30       Impact factor: 9.776

4.  An epidermal growth factor-like repeat of Del1 protein increases the efficiency of gene transfer in vitro.

Authors:  Hisataka Kitano; Chiaki Hidai; Masatoshi Kawana; Shinichiro Kokubun
Journal:  Mol Biotechnol       Date:  2008-03-06       Impact factor: 2.695

5.  A new helper phospholipid for gene delivery.

Authors:  Carla A H Prata; Yougen Li; Dan Luo; Thomas J McIntosh; Philippe Barthelemy; Mark W Grinstaff
Journal:  Chem Commun (Camb)       Date:  2008-01-29       Impact factor: 6.222

6.  Lipophilic peptides for gene delivery.

Authors:  Carla A H Prata; Xiao-Xiang Zhang; Dan Luo; Thomas J McIntosh; Philippe Barthelemy; Mark W Grinstaff
Journal:  Bioconjug Chem       Date:  2008-01-11       Impact factor: 4.774

7.  Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example.

Authors:  Quinn K T Ng; Marie K Sutton; Pan Soonsawad; Li Xing; Holland Cheng; Tatiana Segura
Journal:  Mol Ther       Date:  2009-02-24       Impact factor: 11.454

8.  Enhanced gene delivery using disulfide-crosslinked low molecular weight polyethylenimine with listeriolysin o-polyethylenimine disulfide conjugate.

Authors:  Suna Choi; Kyung-Dall Lee
Journal:  J Control Release       Date:  2008-07-15       Impact factor: 9.776

9.  Poly(2 deoxy 2 methacrylamido glucopyranose) b Poly(methacrylate amine)s: Optimization of Diblock Glycopol ycations for Nucleic Acid Delivery.

Authors:  Haibo Li; Mallory A Cortez; Haley R Phillips; Yaoying Wu; Theresa M Reineke
Journal:  ACS Macro Lett       Date:  2013-03-19       Impact factor: 6.903

Review 10.  Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

Authors:  Omid Veiseh; Jonathan W Gunn; Miqin Zhang
Journal:  Adv Drug Deliv Rev       Date:  2009-11-10       Impact factor: 15.470
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