BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potentially useful treatment for major depression. Nonpsychotic depressed patients appear to have a better outcome than those with psychotic symptoms. METHODS: We report findings in a patient suffering from recurrent, nonpsychotic major depression (DSM-IV) who had 13 daily sessions of rTMS monotherapy within a 3 week period. RESULTS: During rTMS treatment, the patient developed recurrent severe delusions, which he had never experienced before. Psychotic symptoms remitted quickly with neuroleptic medication. CONCLUSIONS: In light of preclinical findings showing increased dopaminergic activity after rTMS treatment, occurrence of psychotic symptoms should be considered a potential side effect of rTMS treatment.
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potentially useful treatment for major depression. Nonpsychotic depressedpatients appear to have a better outcome than those with psychotic symptoms. METHODS: We report findings in a patient suffering from recurrent, nonpsychotic major depression (DSM-IV) who had 13 daily sessions of rTMS monotherapy within a 3 week period. RESULTS: During rTMS treatment, the patient developed recurrent severe delusions, which he had never experienced before. Psychotic symptoms remitted quickly with neuroleptic medication. CONCLUSIONS: In light of preclinical findings showing increased dopaminergic activity after rTMS treatment, occurrence of psychotic symptoms should be considered a potential side effect of rTMS treatment.
Authors: Guilhem Carle; Mehdi Touat; Nicolas Bruno; Damien Galanaud; Charles-Siegfried Peretti; Antoni Valero-Cabré; Richard Levy; Carole Azuar Journal: Front Psychiatry Date: 2017-05-30 Impact factor: 4.157
Authors: Roberto Limongi; Michael Mackinley; Kara Dempster; Ali R Khan; Joseph S Gati; Lena Palaniyappan Journal: Eur Arch Psychiatry Clin Neurosci Date: 2020-07-19 Impact factor: 5.270