F Pfeffer1, M Grube. 1. Klinik für Psychiatrie und Psychotherapie der Städtischen Kliniken a M-Höchst, Frankfurt, Germany.
Abstract
OBJECTIVE: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. METHODS: Clinical observation and further investigations including monitoring of serum levels (case report). RESULTS: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. CONCLUSIONS: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.
OBJECTIVE: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. METHODS: Clinical observation and further investigations including monitoring of serum levels (case report). RESULTS: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. CONCLUSIONS: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.
Authors: M E Friedrich; R Grohmann; U Rabl; D Winkler; A Konstantinidis; R Engel; J Seifert; S Toto; S Stübner; R Frey; S Kasper Journal: Int J Neuropsychopharmacol Date: 2022-08-04 Impact factor: 5.678