Literature DB >> 11947439

Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system.

P Chandra1, C Zimmer, H Thrum.   

Abstract

It is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA-polymerase system is due to the interference of the antibiotic with DNA.

Entities:  

Year:  1970        PMID： 11947439     DOI： 10.1016/0014-5793(70)80626-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Binding of netropsin to DNA and synthetic polynucleotides.

Authors:  A S Zasedatelev; G V Gursky; C Zimmer; H Thrum
Journal:  Mol Biol Rep       Date:  1974-03       Impact factor: 2.316

2.  Protection of (dA.dT) cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin.

Authors:  C Zimmer; G Luck; R Nüske
Journal:  Nucleic Acids Res       Date:  1980-07-11       Impact factor: 16.971

3.  Influence of some antitumor antibiotics on viral neoplasia. The role of molecular structure in the inhibition of DNA polymerases from RNA tumor viruses, viral multiplication and tumor growth by some antitumor antibiotics.

Authors:  P Chandra; A Di Marco; F Zunino; A M Casazza; D Gericke; F Giuliani; C Soranzo; R Thorbeck; A Götz; F Arcamone; M Ghione
Journal:  Naturwissenschaften       Date:  1972-10

4.  Congocidine and distamycin A, antipoxvirus antibiotics.

Authors:  Y Becker; Y Asher; Z Zakay-Rones
Journal:  Antimicrob Agents Chemother       Date:  1972-06       Impact factor: 5.191
  4 in total

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