Literature DB >> 11943389

Magnetic resonance imaging study of the swelling kinetics of hydroxypropylmethylcellulose (HPMC) in water.

Jadwiga Tritt-Goc1, Narcyz Piślewski.   

Abstract

Magnetic resonance imaging has been used to monitor the hydration of hydroxypropylmethylcellulose samples by two-dimensional mapping of properties such as spin density and relaxation times. The measurements were performed at two pH values of water: 2 and 6 and two temperatures 25 and 37 degrees C. It is shown that transport behavior of water into HPMC changes from being almost completely relaxation controlled (case II) at pH=2 to Fickian behavior for pH=6. It was also observed that radial swelling is larger for the system composed of HPMC and water at pH=6 than at pH=2.

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Year:  2002        PMID： 11943389     DOI： 10.1016/s0168-3659(01)00556-9

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  5 in total

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2.  Bioadhesive Drug Delivery System for Enhancing the Permeability of a BCS Class III Drug via Hot-Melt Extrusion Technology.

Authors:  Nicole S Mendonsa; Priyanka Thipsay; Dong Wuk Kim; Scott T Martin; Michael A Repka
Journal:  AAPS PharmSciTech       Date:  2017-02-28       Impact factor: 3.246

Review 3.  Budding Multi-matrix Technology-a Retrospective Approach, Deep Insights, and Future Perspectives.

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Journal:  AAPS PharmSciTech       Date:  2021-11-03       Impact factor: 3.246

4.  Magnetic resonance imaging and image analysis for assessment of HPMC matrix tablets structural evolution in USP Apparatus 4.

Authors:  Piotr Kulinowski; Przemysław Dorożyński; Anna Młynarczyk; Władysław P Węglarz
Journal:  Pharm Res       Date:  2010-12-23       Impact factor: 4.200

5.  Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties: Case Study-Hypromellose (HPMC).

Authors:  P Zarmpi; T Flanagan; E Meehan; J Mann; N Fotaki
Journal:  AAPS J       Date:  2020-02-18       Impact factor: 4.009
  5 in total

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