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Literature DB >> 11943384

Biodegradable injectable in situ forming drug delivery systems.

Abstract

The ability to inject a drug incorporated into a polymer to a localized site and have the polymer form a semi-solid drug depot has a number of advantages. Among these advantages is ease of application and localized, prolonged drug delivery. For these reasons a large number of in situ setting polymeric delivery systems have been developed and investigated for use in delivering a wide variety of drugs. In this article we introduce the various strategies that have been used to prepare in situ setting systems, and outline their advantages and disadvantages as localized drug delivery systems.

Entities: Chemical

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Year: 2002 PMID： 11943384 DOI： 10.1016/s0168-3659(02)00008-1

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

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Cited

61 in total

1. Thermoresponsive hyperbranched copolymer with multi acrylate functionality for in situ cross-linkable hyaluronic acid composite semi-IPN hydrogel.

Authors: Yixiao Dong; Waqar Hassan; Yu Zheng; Aram Omer Saeed; Hongliang Cao; Hongyun Tai; Abhay Pandit; Wenxin Wang
Journal: J Mater Sci Mater Med Date: 2011-12-06 Impact factor: 3.896

2. A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo.

Authors: Xia Lin; Shenshen Yang; Jingxin Gou; Mingming Zhao; Yu Zhang; Na Qi; Haibing He; Cuifang Cai; Xing Tang; Penghong Guo
Journal: J Mater Sci Mater Med Date: 2011-12-15 Impact factor: 3.896

Biodegradable injectable in situ forming drug delivery systems.

1. Thermoresponsive hyperbranched copolymer with multi acrylate functionality for in situ cross-linkable hyaluronic acid composite semi-IPN hydrogel.

2. A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo.

3. Effect of injection site on in situ implant formation and drug release in vivo.

4. Protein polymer hydrogels by in situ, rapid and reversible self-gelation.

5. In vitro and in vivo drug release from a novel in situ forming drug delivery system.

6. Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.

7. Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.

8. In situ-forming pharmaceutical organogels based on the self-assembly of L-alanine derivatives.

9. Thermosensitive Pluronic hydrogel: prolonged injectable formulation for drug abuse.

10. In situ forming polymeric drug delivery systems.