Literature DB >> 11943184

The gift of Gab.

Yan Liu1, Larry R Rohrschneider.   

Abstract

Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.

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Year:  2002        PMID： 11943184     DOI： 10.1016/s0014-5793(02)02425-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  73 in total

1.  G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.

Authors:  Muneyoshi Futami; Quan-Sheng Zhu; Zakary L Whichard; Ling Xia; Yuehai Ke; Benjamin G Neel; Gen-Sheng Feng; Seth J Corey
Journal:  Blood       Date:  2011-06-02       Impact factor: 22.113

2.  Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.

Authors:  Angel W Lee; Yingwei Mao; Josef M Penninger; Soojie Yu
Journal:  Mol Cell Biol       Date:  2011-09-19       Impact factor: 4.272

Review 3.  The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's disease.

Authors:  Xiao-Ling Pan; Ru-Jing Ren; Gang Wang; Hui-Dong Tang; Sheng-Di Chen
Journal:  Neurosci Bull       Date:  2010-06       Impact factor: 5.203

4.  The signaling adapter, FRS2, facilitates neuronal branching in primary cortical neurons via both Grb2- and Shp2-dependent mechanisms.

Authors:  Li Zhou; Asghar Talebian; Susan O Meakin
Journal:  J Mol Neurosci       Date:  2014-08-27       Impact factor: 3.444

5.  Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.

Authors:  Caleb B McDonald; Vikas Bhat; David C Mikles; Brian J Deegan; Kenneth L Seldeen; Amjad Farooq
Journal:  FEBS J       Date:  2012-05-09       Impact factor: 5.542

6.  Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.

Authors:  Ute Schaeper; Regina Vogel; Jolanta Chmielowiec; Joerg Huelsken; Marta Rosario; Walter Birchmeier
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-19       Impact factor: 11.205

7.  Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

Authors:  Rizwan Yousaf; Zubair M Ahmed; Arnaud Pj Giese; Robert J Morell; Ayala Lagziel; Alain Dabdoub; Edward R Wilcox; Sheikh Riazuddin; Thomas B Friedman; Saima Riazuddin
Journal:  J Clin Invest       Date:  2018-03-12       Impact factor: 14.808

Review 8.  Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.

Authors:  Lily A Chylek; Leonard A Harris; Chang-Shung Tung; James R Faeder; Carlos F Lopez; William S Hlavacek
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2013-09-30

9.  Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.

Authors:  Martina Seiffert; Joseph M Custodio; Ingrid Wolf; Michael Harkey; Yan Liu; Joseph N Blattman; Philip D Greenberg; Larry R Rohrschneider
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

10.  Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.

Authors:  Sho Yamasaki; Keigo Nishida; Machie Sakuma; Donna Berry; C Jane McGlade; Toshio Hirano; Takashi Saito
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272
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