BACKGROUND/AIMS: High hemostasis rates for ruptured esophageal varices have been acquired, but many patients die of liver failure afterwards. The aim of the current study is to find clinical information about the patients with ruptured esophageal varices who died during an early period after acquiring a hemostasis. METHODOLOGY: Forty-five patients with ruptured esophageal varices, including 17 who died during two months after acquiring a hemostasis by an initial endoscopic therapy, were investigated in the current study. The relationship between the clinical data and the prognosis of the patients were examined. RESULTS: The proportion of cases with Child-Pugh C in patients who died after therapy significantly higher than that in survivors (P < 0.01). The level of hemoglobin in patients who died was significantly lower than that in the survivors (P < 0.01). Moreover the proportion of an elevation of serum C-reactive protein in patients who died was significantly higher than that of the survivors (P < 0.05). CONCLUSIONS: Our investigation suggested that the elevation of serum C-reactive protein level and a devastated liver function influenced by hemorrhage may be indicators of unfavorable outcomes of the patients with ruptured esophageal varices.
BACKGROUND/AIMS: High hemostasis rates for ruptured esophageal varices have been acquired, but many patients die of liver failure afterwards. The aim of the current study is to find clinical information about the patients with ruptured esophageal varices who died during an early period after acquiring a hemostasis. METHODOLOGY: Forty-five patients with ruptured esophageal varices, including 17 who died during two months after acquiring a hemostasis by an initial endoscopic therapy, were investigated in the current study. The relationship between the clinical data and the prognosis of the patients were examined. RESULTS: The proportion of cases with Child-Pugh C in patients who died after therapy significantly higher than that in survivors (P < 0.01). The level of hemoglobin in patients who died was significantly lower than that in the survivors (P < 0.01). Moreover the proportion of an elevation of serum C-reactive protein in patients who died was significantly higher than that of the survivors (P < 0.05). CONCLUSIONS: Our investigation suggested that the elevation of serum C-reactive protein level and a devastated liver function influenced by hemorrhage may be indicators of unfavorable outcomes of the patients with ruptured esophageal varices.
Authors: Andry Van de Louw; Nadine Lasserre; François Drouhin; Stéphane Thierry; Lucien Lecuyer; Daniel Caen; Alain Tenaillon Journal: Intensive Care Med Date: 2006-12-05 Impact factor: 17.440