OBJECTIVE: The study was designed to examine the antidotal effects of vitamin B(6) (Vit B(6)) with sodium dimercaptopropane sulfonate (Na-DMPS) on acute poisoning with tetramethylene disulphotetramine (TETS) in animals. METHODS: Through the acute toxicity experiments, the antidotal effects of Vit B(6) with Na-DMPS on mice immediately and 10 minutes after poisoning were observed. RESULTS: Used of Vit B(6) with Na-DMPS in early stage showed excellent inhibition of tetanic convulsion in acute poisoning with TETS in mice and can reduce very significantly the death rate (P < 0.001). Vit B(6) with Na-DMPS used 10 minutes after poisoning also significantly elongate the death time (68.8 +/- 15.2) and reduce significantly the death rate (60%) then control group's death time (31.6 +/- 7.8) and the death rate (100%) on acute poisoning in mice (P < 0.01). CONCLUSION: Antidotal effects of Vit B(6) with Na-DMPS were significant on acute TETS poisoning in animals. Vit B(6) with Na-DMPS is an excellent antidote for acute TETS poisoning. It is suggested that Vit B(6) with Na-DMPS may be clinically used to rescue patients poisoned by TETS.
OBJECTIVE: The study was designed to examine the antidotal effects of vitamin B(6) (Vit B(6)) with sodium dimercaptopropane sulfonate (Na-DMPS) on acute poisoning with tetramethylene disulphotetramine (TETS) in animals. METHODS: Through the acute toxicity experiments, the antidotal effects of Vit B(6) with Na-DMPS on mice immediately and 10 minutes after poisoning were observed. RESULTS: Used of Vit B(6) with Na-DMPS in early stage showed excellent inhibition of tetanic convulsion in acute poisoning with TETS in mice and can reduce very significantly the death rate (P < 0.001). Vit B(6) with Na-DMPS used 10 minutes after poisoning also significantly elongate the death time (68.8 +/- 15.2) and reduce significantly the death rate (60%) then control group's death time (31.6 +/- 7.8) and the death rate (100%) on acute poisoning in mice (P < 0.01). CONCLUSION: Antidotal effects of Vit B(6) with Na-DMPS were significant on acute TETS poisoning in animals. Vit B(6) with Na-DMPS is an excellent antidote for acute TETS poisoning. It is suggested that Vit B(6) with Na-DMPS may be clinically used to rescue patients poisoned by TETS.
Authors: Chunqing Zhao; Sung Hee Hwang; Bruce A Buchholz; Timothy S Carpenter; Felice C Lightstone; Felice Lightstone; Jun Yang; Bruce D Hammock; John E Casida Journal: Proc Natl Acad Sci U S A Date: 2014-05-27 Impact factor: 11.205