BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.
BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.
Authors: Henriette J Tschampa; Petra Mürtz; Sebastian Flacke; Sebastian Paus; Hans H Schild; Horst Urbach Journal: AJNR Am J Neuroradiol Date: 2003-05 Impact factor: 3.825
Authors: Meghdeep Sen; Juan A Moncayo; Maria A Kelley; Deydie Suarez Salazar; Maria Gabriela Tenemaza; Mikaela Camacho; Gashaw Hassen; Guillermo E Lopez; Gustavo Monteros; Gabriela Garofalo; Ayush Yadav; Juan Fernando Ortiz Journal: Cureus Date: 2022-07-19
Authors: Christina D Orrù; Katrin Soldau; Christian Cordano; Jorge Llibre-Guerra; Ari J Green; Henry Sanchez; Bradley R Groveman; Steven D Edland; Jiri G Safar; Jonathan H Lin; Byron Caughey; Michael D Geschwind; Christina J Sigurdson Journal: mBio Date: 2018-11-20 Impact factor: 7.867