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Literature DB >> 11939267

Acute myelogenous leukemia concurrent with untreated chronic lymphocytic leukemia.

Tsuyoshi Muta¹, Takashi Okamura, Yoshiyuki Niho.

Abstract

We report a case of acute myelogenous leukemia (AML) concurrent with untreated chronic lymphocytic leukemia (CLL). An 84-year-old Japanese man was admitted to the Chihaya Hospital with persistent high-grade fever. Morphologic observation of peripheral blood and bone marrow smears revealed a proliferation of blasts and lymphocytosis with small and mature phenotypes. Immunophenotyping of the blast cells revealed CD13+, CD33+, CD34+, and HLA-DR+, and that of the lymphocytes revealed CD5+, CD19+, CD20+, and lambda+ on the cell surface. The peripheral lymphocytes revealed an IgH gene rearrangement. Chromosome analysis of 20 metaphase cells from bone marrow showed numerous abnormalities, containing +8,+11,+21. The patient's disease was diagnosed as AML with trilineage dysplasia concurrent with CLL. The simultaneous occurrence of AML and CLL is extremely rare but should not be overlooked as a possible underlying cause of lymphocyte abnormalities in AML patients.

Entities: Disease Gene Species

Mesh：

Year: 2002 PMID： 11939267 DOI： 10.1007/BF02982026

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

16 in total

1. Outcome of biphenotypic acute leukemia.

Authors: S Killick; E Matutes; R L Powles; M Hamblin; J Swansbury; J G Treleaven; A Zomas; A Atra; D Catovsky
Journal: Haematologica Date: 1999-08 Impact factor: 9.941

2. Incidence and characteristics of lymphoid malignancies in untreated myelodysplastic syndromes.

Authors: L Florensa; T Vallespí; S Woessner; A Domingo; N Crespo; M Rozman; J L Aguilar; D Irriguible; A Zarco; F Millá; E Feliu
Journal: Leuk Lymphoma Date: 1996-11

3. Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. International Workshop on Chronic Lymphocytic Leukemia.

Authors:
Journal: Ann Intern Med Date: 1989-02-01 Impact factor: 25.391

Acute myelogenous leukemia concurrent with untreated chronic lymphocytic leukemia.

1. Outcome of biphenotypic acute leukemia.

2. Incidence and characteristics of lymphoid malignancies in untreated myelodysplastic syndromes.

3. Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. International Workshop on Chronic Lymphocytic Leukemia.

4. Chronic lymphocytic leukaemia associated with acute myelomonocytic leukaemia.

5. Concomitant chronic lymphocytic leukemia and acute myeloid leukemia with an uncommon immunophenotype.

6. Therapy-related leukemia and myelodysplastic syndrome in chronic lymphocytic leukemia.

7. Acute myeloid leukaemia occurring in untreated chronic lymphatic leukaemia.

8. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.

9. CD7 expression in acute myeloid leukemia.

10. Chronic lymphatic leukemia terminating in acute myeloid leukemia: review of the literature.

1. A Case of Acute Myeloid Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia.

2. Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy.