H Wang1, S Lai, J Sun. 1. Department of Neurobiology, Faculty of Anatomy, Shandong Medical University, Jinan 250012.
Abstract
OBJECTIVE: To explore the ethological improving effect of Bushen Yizhi Decoction (BSYZD) in treating model rat of Alzheimer's disease (AD). METHODS: Ethologic examination was carried out with Morris water maze on young, aged, AD model, Huperzine A treated and BSYZD treated groups of rats. RESULTS: In the BSYZD treated group, the escape latency (EL) curve placed between that of the young, aged and AD model, Huperzine A treated group; the percentage of middle circle swim path, the 40 cm circle swimming time, and the platform-crossing times were not different from those in the normal aged group, but were different significantly as compared with the AD model group, P < 0.05. CONCLUSION: BSYZD could ameliorate the behavior deficits of AD model.
OBJECTIVE: To explore the ethological improving effect of Bushen Yizhi Decoction (BSYZD) in treating model rat of Alzheimer's disease (AD). METHODS: Ethologic examination was carried out with Morris water maze on young, aged, AD model, Huperzine A treated and BSYZD treated groups of rats. RESULTS: In the BSYZD treated group, the escape latency (EL) curve placed between that of the young, aged and AD model, Huperzine A treated group; the percentage of middle circle swim path, the 40 cm circle swimming time, and the platform-crossing times were not different from those in the normal aged group, but were different significantly as compared with the AD model group, P < 0.05. CONCLUSION: BSYZD could ameliorate the behavior deficits of AD model.
Authors: Shi-Jie Zhang; Dan Luo; Lin Li; Rui-Rong Tan; Qing-Qing Xu; Jie Qin; Lei Zhu; Na-Chuan Luo; Ting-Ting Xu; Rong Zhang; Lei Yang; Qi Wang Journal: Sci Rep Date: 2017-08-29 Impact factor: 4.379