| Literature DB >> 11937355 |
Jianhua Qi1, Makoto Ojika, Youji Sakagami.
Abstract
Two new steroid glycosides, named linckosides A and B, were isolated from the Okinawan starfish Linckia laevigata, and their stereostructures were elucidated by spectroscopic methods and chemical derivatization. Each of them possesses two monosaccharide units at C-3 and C-29 of a polyhydroxylated steroid aglycon. These steroid glycosides showed not only notable neuritogenic activity against PC12 cells but also significant synergistic effects on the NGF-induced neuronal differentiation of PC12 cells. Linckoside B showed higher activities than those of linckoside A, though the structural difference is only the kind of a sugar.Entities:
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Year: 2002 PMID： 11937355 DOI： 10.1016/s0968-0896(02)00006-8
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641