Literature DB >> 11937007

Gender issues and multiple sclerosis.

Rhonda R Voskuhl1.   

Abstract

Gender-related issues in multiple sclerosis include the important and widely accepted clinical observations that men are less susceptible to the disease than women and also that disease activity in multiple sclerosis is decreased during late pregnancy. This article reviews mechanisms underlying each of these clinical observations and discusses the role of sex hormones in each. Specifically, the protective role of testosterone in young men and the protective role of the pregnancy hormone estriol in pregnant women are discussed. Rationale for novel therapies in multiple sclerosis based on the protective roles of these sex hormones is presented.

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Year:  2002        PMID： 11937007     DOI： 10.1007/s11910-002-0087-1

Source DB:  PubMed          Journal:  Curr Neurol Neurosci Rep        ISSN： 1528-4042            Impact factor:   5.081


  78 in total

1.  A gender gap in autoimmunity.

Authors:  C C Whitacre; S C Reingold; P A O'Looney
Journal:  Science       Date:  1999-02-26       Impact factor: 47.728

2.  Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response.

Authors:  M Dalal; S Kim; R R Voskuhl
Journal:  J Immunol       Date:  1997-07-01       Impact factor: 5.422

3.  Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy.

Authors:  M Marzi; A Vigano; D Trabattoni; M L Villa; A Salvaggio; E Clerici; M Clerici
Journal:  Clin Exp Immunol       Date:  1996-10       Impact factor: 4.330

4.  Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis.

Authors:  S Kim; S M Liva; M A Dalal; M A Verity; R R Voskuhl
Journal:  Neurology       Date:  1999-04-12       Impact factor: 9.910

5.  17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis.

Authors:  A Matejuk; K Adlard; A Zamora; M Silverman; A A Vandenbark; H Offner
Journal:  J Neurosci Res       Date:  2001-09-15       Impact factor: 4.164

6.  Effect of estriol administration on the hypogonadal woman.

Authors:  I Schiff; B Wentworth; B Koos; K J Ryan; D Tulchinsky
Journal:  Fertil Steril       Date:  1978-09       Impact factor: 7.329

Review 7.  Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.

Authors:  R R Voskuhl; K Palaszynski
Journal:  Neuroscientist       Date:  2001-06       Impact factor: 7.519

8.  The influence of testosterone on the development of autoimmune thyroiditis in thymectomized and irradiated rats.

Authors:  S A Ahmed; W J Penhale
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

9.  Oral contraceptives and reproductive factors in multiple sclerosis incidence.

Authors:  L Villard-Mackintosh; M P Vessey
Journal:  Contraception       Date:  1993-02       Impact factor: 3.375

10.  The clinical course of multiple sclerosis during pregnancy and the puerperium.

Authors:  K Birk; C Ford; S Smeltzer; D Ryan; R Miller; R A Rudick
Journal:  Arch Neurol       Date:  1990-07
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  9 in total

Review 1.  Understanding sex biases in immunity: effects of estrogen on the differentiation and function of antigen-presenting cells.

Authors:  Greg Nalbandian; Susan Kovats
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

Review 2.  Effects of the Menstrual Cycle on Neurological Disorders.

Authors:  Hannah J Roeder; Enrique C Leira
Journal:  Curr Neurol Neurosci Rep       Date:  2021-05-10       Impact factor: 5.081

3.  Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE.

Authors:  H H Hofstetter; R Mössner; K P Lesch; R A Linker; K V Toyka; R Gold
Journal:  Clin Exp Immunol       Date:  2005-10       Impact factor: 4.330

4.  Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice.

Authors:  Seema Tiwari-Woodruff; Rhonda R Voskuhl
Journal:  J Neurol Sci       Date:  2009-05-13       Impact factor: 3.181

5.  Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei.

Authors:  William Byne; Stella Dracheva; Benjamin Chin; James M Schmeidler; Kenneth L Davis; Vahram Haroutunian
Journal:  Schizophr Res       Date:  2007-10-29       Impact factor: 4.939

6.  Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis.

Authors:  Parley D Fillmore; Elizabeth P Blankenhorn; James F Zachary; Cory Teuscher
Journal:  Am J Pathol       Date:  2004-01       Impact factor: 4.307

7.  Spatial memory and long-term object recognition are impaired by circadian arrhythmia and restored by the GABAAAntagonist pentylenetetrazole.

Authors:  Norman F Ruby; Fabian Fernandez; Alex Garrett; Jessy Klima; Pei Zhang; Robert Sapolsky; H Craig Heller
Journal:  PLoS One       Date:  2013-08-29       Impact factor: 3.240

8.  Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years.

Authors:  Wan Hu; Lanlan Fang; Ruyu Ni; Hengchuan Zhang; Guixia Pan
Journal:  BMC Cancer       Date:  2022-07-30       Impact factor: 4.638

Review 9.  Neurobehavioral burden of multiple sclerosis with nanotheranostics.

Authors:  Bhasker Sriramoju; Rupinder K Kanwar; Jagat R Kanwar
Journal:  Neuropsychiatr Dis Treat       Date:  2015-10-15       Impact factor: 2.570
  9 in total

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