Literature DB >> 11936510

Ultrastructural alterations induced by nifurtimox and another nitro derivative on epimastigotes of Trypanosoma cruzi.

S Muelas-Serrano1, J Pérez-Serrano, A Gómez-Barrio, V J Arán, F Rodríguez-Caabeiro.   

Abstract

We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.

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Year:  2002        PMID： 11936510     DOI： 10.1007/s004360100497

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  2 in total

1.  Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity.

Authors:  Aline Cavalcanti de Queiroz; Gisele Barbosa; Victória Regina Thomaz de Oliveira; Hélio de Mattos Alves; Marina Amaral Alves; Vanessa Carregaro; João Santana da Silva; Eliezer Jesus Barreiro; Magna Suzana Alexandre-Moreira; Lidia Moreira Lima
Journal:  PLoS One       Date:  2022-06-06       Impact factor: 3.752

2.  Novel 5-(nitrothiophene-2-yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity against promastigote stage of Leishmania major.

Authors:  Seyed Esmail Sadat-Ebrahimi; Maryam Mirmohammadi; Zahra Mojallal Tabatabaei; Marjan Azimzadeh Arani; Sogol Jafari-Ashtiani; Mahsa Hashemian; Parham Foroumadi; Azadeh Yahya-Meymandi; Setareh Moghimi; Mohammad Hassan Moshafi; Peiman Norouzi; Susan Kabudanian Ardestani; Alireza Foroumadi
Journal:  Iran J Pharm Res       Date:  2019       Impact factor: 1.696
  2 in total

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