Literature DB >> 1193599

Human triploid cell strain. Phenotype on cellular level.

A M Kuliev, V I Kukharenko, K N Grinberg, A T Mikhailov, A D Tamarkina.   

Abstract

The complex investigation of the bilogical properties of the triploid cell strain derived from a spontaneous abortus was carried out. Cytomorphological, autoradiographic, cytochemical, biochemical and immunochemical investigation showed that, according to most of the investigated properties, triploid cells did not differ from normal diploid cells. The cells had normal form, were well orientated, revealed expressed fibrillar apparatus and viability in the culture during 15--17 passages. The decrease of the alkaline phosphatase level, increase of acid phosphatase, lactate and malatdehydrogenase and greater nuclei area were the essential differences from the control. The cells had normal mitotic cycle parameters and the antigenic spectrum was practically identical to the normal cells.

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Year:  1975        PMID: 1193599     DOI: 10.1007/bf00291945

Source DB:  PubMed          Journal:  Humangenetik        ISSN: 0018-7348


  12 in total

1.  Growth characteristics of human embryonic cell lines with chromosomal anomalies.

Authors:  S Cure; J Boué; A Boué
Journal:  Biomedicine       Date:  1974-05-20

2.  Investigation of a cell strain with trisomy 14 from a spontaneously aborted human fetus.

Authors:  A M Kuliev; V I Kukharenko; K N Grinberg; V V Terskikh; A D Tamarkina; E A Bogomazov; P S Redkin; S S Vasileysky
Journal:  Humangenetik       Date:  1974-01-22

3.  Genotype and phenotype in human chromosome aberrations and in the minute mutants of Drosophila melanogaster.

Authors:  F Vogel
Journal:  Humangenetik       Date:  1973

4.  Morphological, autoradiographic, immunochemical and cytochemical investigation of a cell strain with trisomy 7 from a spontaneous abortus.

Authors:  A M Kuliev; V I Kukharenko; K N Grinberg; S S Vasileysky; V V Terskikh; L G Stepanova
Journal:  Humangenetik       Date:  1973

5.  [Spontaneous abortions and triploidy].

Authors:  J Levy; P A Chadeyron; B Fonty
Journal:  Rev Fr Gynecol Obstet       Date:  1972-05

6.  Chromosome studies in selected spontaneous abortions. Polyploidy in man.

Authors:  D H Carr
Journal:  J Med Genet       Date:  1971-06       Impact factor: 6.318

7.  [Human cell lines with chromosome aberrations (trisomy, monosomy and triploid cells), karyotype stability and longevity].

Authors:  A Boué; J G Boué; E Deshayes
Journal:  Pathol Biol       Date:  1968-12

8.  [The placenta in lethal chromosome aberrations].

Authors:  E Philippe; J G Boué
Journal:  Ann Anat Pathol (Paris)       Date:  1969 Jul-Sep

9.  Anatomic findings in human abortions of known chromosomal constitution.

Authors:  R P Singh; D H Carr
Journal:  Obstet Gynecol       Date:  1967-06       Impact factor: 7.661

10.  Three cases of triploidy in man.

Authors:  J H Edwards; C Yuncken; D I Rushton; S Richards; U Mittwoch
Journal:  Cytogenetics       Date:  1967
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  4 in total

1.  Monosomy 21 in a human spontaneous abortus. Morphogenetic disturbances and phenotype at the cellular level.

Authors:  A M Kuliev; K N Grinberg; V I Kukharenko; V P Kulazenko; E A Bogomazov
Journal:  Hum Genet       Date:  1977-09-22       Impact factor: 4.132

2.  Collagen and fibronectin synthesis by trisomic and triploid fibroblasts from human spontaneous abortuses.

Authors:  A A Delvig; V I Kukharenko; V M Belkin; V I Mazurov; K N Grinberg; S S Debov
Journal:  Mol Gen Genet       Date:  1987-10

3.  Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos.

Authors:  V I Kukharenko; A A Delvig; K N Grinberg
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  Synthesis of glycosaminoglycans in fibroblasts from abortuses with trisomy, triploidy, and from children with Down's syndrome.

Authors:  V I Kukharenko; E M Pichugina; M I Freidin; E A Kirillova; O A Smirnova; A A Delvig
Journal:  Hum Genet       Date:  1991-09       Impact factor: 4.132

  4 in total

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