OBJECTIVE: To determine the feasibility of creating a perivascular space adjacent to the central retinal vein at the level of the lamina cribrosa as a potential method of reestablishing perfusion in central retinal vein occlusion. METHODS: Various designs for a puncture instrument, or lamina puncture lancet, were investigated in cadavers, pigs that had undergone enucleation, and in vivo rabbit eyes. RESULTS: A lancet with a sharp cutting edge on one side and an opposing blunt edge is repeatedly able to create a perivascular space with limited optic nerve fiber damage. CONCLUSIONS: Lamina puncture is technically feasible, and evaluation in carefully selected patients appears warranted.
OBJECTIVE: To determine the feasibility of creating a perivascular space adjacent to the central retinal vein at the level of the lamina cribrosa as a potential method of reestablishing perfusion in central retinal vein occlusion. METHODS: Various designs for a puncture instrument, or lamina puncture lancet, were investigated in cadavers, pigs that had undergone enucleation, and in vivo rabbit eyes. RESULTS: A lancet with a sharp cutting edge on one side and an opposing blunt edge is repeatedly able to create a perivascular space with limited optic nerve fiber damage. CONCLUSIONS: Lamina puncture is technically feasible, and evaluation in carefully selected patients appears warranted.
Authors: H J Zambarakji; S Ghazi-Nouri; M Schadt; C Bunce; P G Hykin; D G Charteris Journal: Graefes Arch Clin Exp Ophthalmol Date: 2004-11-17 Impact factor: 3.117
Authors: Michael W Gaynon; Yannis M Paulus; Ehsan Rahimy; Janet L Alexander; Sam E Mansour Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-02-04 Impact factor: 3.117
Authors: Ingrid U Scott; Paul C VanVeldhuisen; Michael S Ip; Barbara A Blodi; Neal L Oden; Maria Figueroa; Pravin U Dugel Journal: Ophthalmology Date: 2016-11-15 Impact factor: 12.079
Authors: Michael S Ip; Neal L Oden; Ingrid U Scott; Paul C VanVeldhuisen; Barbara A Blodi; Maria Figueroa; Andrew Antoszyk; Michael Elman Journal: Ophthalmology Date: 2009-07-19 Impact factor: 12.079